Khaled Abduljalil

TL;DR: The collected data presented in this paper provide a potentially useful singular resource for key parameters needed for PBPK modelling in pregnancy, which facilitates the risk assessment of environmental chemicals and therapeutic drug dose adjustments in the pregnant population.

TL;DR: These findings challenge the assertion that GE is different in neonates, as compared with older children and adults due to age, and they reinforce the significance of food type in modulating GE.

TL;DR: In the absence of clinical data, the in silico prediction of PK behaviour during pregnancy can provide a valuable aid to dose adjustment in pregnant women.

TL;DR: In this paper, the authors report ontogeny functions for these enzymes as paediatric to adult relative intrinsic clearance per mg of hepatic microsomal protein, based on the deconvolution of in vivo pharmacokinetic data and by accounting for the impact of known clinical condition on hepatic unbound intrinsic clearance for caffeine and theophylline as markers of CYP1A2 activity and for midazolam as a marker of CHP3A4 activity.

TL;DR: Analysis of published systemic clearance and volume of distribution at steady state (Vss) values taken from over 200 clinical studies shows that in some cases the twofold criteria method is an unreasonable expectation when the observed data are obtained from studies with small sample size.