In this Outlook paper, we explain why an accurate physiological interpretation of functional near-infrared spectroscopy (fNIRS) neuroimaging signals is facilitated when systemic physiological activity (e.g., cardiorespiratory and autonomic activity) is measured simultaneously by employing systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS). The rationale for SPA-fNIRS is twofold: (i) SPA-fNIRS enables a more complete interpretation and understanding of the fNIRS signals measured at the head since they contain components originating from neurovascular coupling and from systemic physiological sources. The systemic physiology signals measured with SPA-fNIRS can be used for regressing out physiological confounding components in fNIRS signals. Misinterpretations can thus be minimized. (ii) SPA-fNIRS enables to study the embodied brain by linking the brain with the physiological state of the entire body, allowing novel insights into their complex interplay. We envisage the SPA-fNIRS approach will become increasingly important in the future. 

/pdf/systemic-physiology-augmented-functional-near-infrared-ew5p0urn.pdf

Systemic physiology augmented functional near-infrared spectroscopy: a powerful approach to study the embodied human brain

Extubation in neurocritical care patients: the ENIO international prospective study

One of the most promising research areas in the healthcare industry and the scientific community is focusing on the AI-based applications for real medical challenges such as the building of computer-aided diagnosis (CAD) systems for breast cancer. Transfer learning is one of the recent emerging AI-based techniques that allow rapid learning progress and improve medical imaging diagnosis performance. Although deep learning classification for breast cancer has been widely covered, certain obstacles still remain to investigate the independency among the extracted high-level deep features. This work tackles two challenges that still exist when designing effective CAD systems for breast lesion classification from mammograms. The first challenge is to enrich the input information of the deep learning models by generating pseudo-colored images instead of only using the input original grayscale images. To achieve this goal two different image preprocessing techniques are parallel used: contrast-limited adaptive histogram equalization (CLAHE) and Pixel-wise intensity adjustment. The original image is preserved in the first channel, while the other two channels receive the processed images, respectively. The generated three-channel pseudo-colored images are fed directly into the input layer of the backbone CNNs to generate more powerful high-level deep features. The second challenge is to overcome the multicollinearity problem that occurs among the high correlated deep features generated from deep learning models. A new hybrid processing technique based on Logistic Regression (LR) as well as Principal Components Analysis (PCA) is presented and called LR-PCA. Such a process helps to select the significant principal components (PCs) to further use them for the classification purpose. The proposed CAD system has been examined using two different public benchmark datasets which are INbreast and mini-MAIS. The proposed CAD system could achieve the highest performance accuracies of 98.60% and 98.80% using INbreast and mini-MAIS datasets, respectively. Such a CAD system seems to be useful and reliable for breast cancer diagnosis.

/pdf/a-hybrid-deep-transfer-learning-of-cnn-based-lr-pca-for-3cb56mc3.pdf

A Hybrid Deep Transfer Learning of CNN-Based LR-PCA for Breast Lesion Diagnosis via Medical Breast Mammograms

Abstract. In this Outlook paper, we explain why an accurate physiological interpretation of functional near-infrared spectroscopy (fNIRS) neuroimaging signals is facilitated when systemic physiological activity (e.g., cardiorespiratory and autonomic activity) is measured simultaneously by employing systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS). The rationale for SPA-fNIRS is twofold: (i) SPA-fNIRS enables a more complete interpretation and understanding of the fNIRS signals measured at the head since they contain components originating from neurovascular coupling and from systemic physiological sources. The systemic physiology signals measured with SPA-fNIRS can be used for regressing out physiological confounding components in fNIRS signals. Misinterpretations can thus be minimized. (ii) SPA-fNIRS enables to study the embodied brain by linking the brain with the physiological state of the entire body, allowing novel insights into their complex interplay. We envisage the SPA-fNIRS approach will become increasingly important in the future.

With the help of machine learning, many of the problems that have plagued mammography in the past have been solved. Effective prediction models need many normal and tumor samples. For medical applications such as breast cancer diagnosis framework, it is difficult to gather labeled training data and construct effective learning frameworks. Transfer learning is an emerging strategy that has recently been used to tackle the scarcity of medical data by transferring pre-trained convolutional network knowledge into the medical domain. Despite the well reputation of the transfer learning based on the pre-trained Convolutional Neural Networks (CNN) for medical imaging, several hurdles still exist to achieve a prominent breast cancer classification performance. In this paper, we attempt to solve the Feature Dimensionality Curse (FDC) problem of the deep features that are derived from the transfer learning pre-trained CNNs. Such a problem is raised due to the high space dimensionality of the extracted deep features with respect to the small size of the available medical data samples. Therefore, a novel deep learning cascaded feature selection framework is proposed based on the pre-trained deep convolutional networks as well as the univariate-based paradigm. Deep learning models of AlexNet, VGG, and GoogleNet are randomly selected and used to extract the shallow and deep features from the INbreast mammograms, whereas the univariate strategy helps to overcome the dimensionality curse and multicollinearity issues for the extracted features. The optimized key features via the univariate approach are statistically significant (p-value ≤ 0.05) and have good capability to efficiently train the classification models. Using such optimal features, the proposed framework could achieve a promising evaluation performance in terms of 98.50% accuracy, 98.06% sensitivity, 98.99% specificity, and 98.98% precision. Such performance seems to be beneficial to develop a practical and reliable computer-aided diagnosis (CAD) framework for breast cancer classification.

/pdf/deep-learning-cascaded-feature-selection-framework-for-157ai6sh.pdf

Deep Learning Cascaded Feature Selection Framework for Breast Cancer Classification: Hybrid CNN with Univariate-Based Approach

Technologies have driven big data collection across many fields, such as genomics and business intelligence. This results in a significant increase in variables and data points (observations) collected and stored. Although this presents opportunities to better model the relationship between predictors and the response variables, this also causes serious problems during data analysis, one of which is the multicollinearity problem. The two main approaches used to mitigate multicollinearity are variable selection methods and modified estimator methods. However, variable selection methods may negate efforts to collect more data as new data may eventually be dropped from modeling, while recent studies suggest that optimization approaches via machine learning handle data with multicollinearity better than statistical estimators. Therefore, this study details the chronological developments to mitigate the effects of multicollinearity and up-to-date recommendations to better mitigate multicollinearity.

/pdf/mitigating-the-multicollinearity-problem-and-its-machine-2f3em3pn.pdf

Mitigating the Multicollinearity Problem and Its Machine Learning Approach: A Review

State of the art: a review of sentiment analysis based on sequential transfer learning

Algorithmic trading is a common topic researched in the neural network due to the abundance of data available. It is a phenomenon where an approximately linear relationship exists between two or more independent variables. It is especially prevalent in financial data due to the interrelated nature of the data. The existing feature selection methods are not efficient enough in solving such a problem due to the potential loss of essential and relevant information. These methods are also not able to consider the interaction between features. Therefore, we proposed two improvements to apply to the Long Short-Term Memory neural network (LSTM) in this study. It is the Multicollinearity Reduction Module (MRM) based on correlation-embedded attention to mitigate multicollinearity without removing features. The motivation of the improvements is to allow the model to predict using the relevance and redundancy within the data. The first contribution of the paper is allowing a neural network to mitigate the effects of multicollinearity without removing any variables. The second contribution is improving trading returns when our proposed mechanisms are applied to an LSTM. This study compared the classification performance between LSTM models with and without the correlation-embedded attention module. The experimental result reveals that a neural network that can learn the relevance and redundancy of the financial data to improve the desired classification performance. Furthermore, the trading returns of our proposed module are 46.82% higher without sacrificing training time. Moreover, the MRM is designed to be a standalone module and is interoperable with existing models.

/pdf/a-correlation-embedded-attention-module-to-mitigate-3iza7yy0.pdf

A Correlation-Embedded Attention Module to Mitigate Multicollinearity: An Algorithmic Trading Application

Stock forecasting is a significant and challenging task. The recent development of web technologies has transformed the communication channel to allow the public to share information over the web such as news, social media contents, etc., thus causing exponential growth of web data. The massively available information might be the key to revealing the financial market’s unexplained variability and facilitating forecasting accuracy. However, this information is usually in unstructured natural language and consists of different inherent meanings. Although a human can easily interpret the inherent messages, it is still complicated to manually process such a massive amount of textual data due to the constraint of time, ability, energy, etc. Due to the different properties of text sources, it is crucial to understand various text processing approaches to optimize forecasting performance. This study attempted to summarize and discuss the current text-based financial forecasting approaches in the aspect of semantic-based, sentiment-based, event-extraction-based, and hybrid approaches. Afterward, the study discussed the strength and weakness of each approach, followed with their comparison and suitable application scenarios. Moreover, this study also highlighted the future research direction in text-based stock forecasting, where the overall discussion is expected to provide insightful analysis for future reference.

/pdf/a-review-of-sentiment-semantic-and-event-extraction-based-3t774qrv.pdf

Khean Thye Bea

Papers

Mitigating the Multicollinearity Problem and Its Machine Learning Approach: A Review

State of the art: a review of sentiment analysis based on sequential transfer learning

A Correlation-Embedded Attention Module to Mitigate Multicollinearity: An Algorithmic Trading Application

A Review of Sentiment, Semantic and Event-Extraction-Based Approaches in Stock Forecasting