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Yen-Lin Chen
Researcher at Harvard University
Publications - 138
Citations - 3705
Yen-Lin Chen is an academic researcher from Harvard University. The author has contributed to research in topics: Radiation therapy & Medicine. The author has an hindex of 30, co-authored 111 publications receiving 2755 citations. Previous affiliations of Yen-Lin Chen include University of Oklahoma & University of Oklahoma Health Sciences Center.
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Journal ArticleDOI
Imaging Steps of Lymphatic Metastasis Reveals That Vascular Endothelial Growth Factor-C Increases Metastasis by Increasing Delivery of Cancer Cells to Lymph Nodes: Therapeutic Implications
Tohru Hoshida,Naohide Isaka,Jeroen Hagendoorn,Emmanuelle di Tomaso,Yen-Lin Chen,Bronislaw Pytowski,Dai Fukumura,Timothy P. Padera,Rakesh K. Jain +8 more
TL;DR: It is indicated that VEGF-C facilitates lymphatic metastasis by increasing the delivery of cancer cells to lymph nodes and therapies directed against VEGf-C/VEGFR-3 signaling target the initial steps of lymphatics metastasis.
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Long‐term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas
Thomas F. DeLaney,Norbert J. Liebsch,Frank X. Pedlow,Judith Adams,Elizabeth A. Weyman,Beow Y. Yeap,Nicolas Depauw,G. Petur Nielsen,David C. Harmon,Sam S. Yoon,Yen-Lin Chen,Joseph H. Schwab,Francis J. Hornicek +12 more
TL;DR: Negative surgical margins are uncommon for spine sarcomas; hence, adjuvant radiotherapy (RT) may be recommended but tumor dose may be constrained by spinal cord, nerve, and viscera tolerance.
Journal ArticleDOI
Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma.
I. Frank Ciernik,I. Frank Ciernik,Andrzej Niemierko,David C. Harmon,Wendy Kobayashi,Yen-Lin Chen,Torunn I. Yock,David H. Ebb,Edwin Choy,Kevin A. Raskin,Norbert J. Liebsch,Francis J. Hornicek,Thomas F. DeLaney +12 more
TL;DR: A study was undertaken to assess clinical outcome and the role of proton therapy for local control of osteosarcoma (OSA).
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The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research.
Corrie A. Painter,Esha Jain,Esha Jain,Brett N. Tomson,Michael Dunphy,Rachel Stoddard,Beena Thomas,Alyssa L. Damon,Shahrayz Shah,Dewey Kim,Dewey Kim,Jorge Gómez Tejeda Zañudo,Jorge Gómez Tejeda Zañudo,Jason L. Hornick,Yen-Lin Chen,Priscilla Merriam,Chandrajit P. Raut,Chandrajit P. Raut,George D. Demetri,Brian A. Van Tine,Eric S. Lander,Todd R. Golub,Todd R. Golub,Nikhil Wagle +23 more
TL;DR: A framework of patient-partnered research allows patients with angiosarcoma to share their samples and clinical records securely to accelerate molecular characterization of tumors and identification of therapeutic approaches, demonstrating that empowering patients to directly participate in research can overcome barriers in rare diseases and can enable discoveries.
Journal ArticleDOI
High-dose proton-based radiation therapy in the management of spine chordomas: outcomes and clinicopathological prognostic factors.
Ronny L. Rotondo,Wendy Folkert,Norbert J. Liebsch,Yen-Lin Chen,Frank X. Pedlow,Joseph H. Schwab,Andrew E. Rosenberg,G. Petur Nielsen,Jackie Szymonifka,Al Ferreira,Francis J. Hornicek,Thomas F. DeLaney +11 more
TL;DR: High-dose proton-based RT in the management of spinal chordomas can be effective treatment and in patients undergoing surgery, those with primary chordomas undergoing preoperative RT, en bloc resection, and postoperative RT boost have the highest rate of local tumor control.