Kihito Takahashi

TL;DR: Competitive radioligand binding studies demonstrated that 8-epi-PGF2 alpha is a potent competitor for [3H]SQ 29,548 binding to rat renal arterial smooth muscle cells (RASM) in culture, which may explain the beneficial effects of antioxidant therapy and TxA2 antagonism observed in numerous models of renal injury induced by lipid peroxidation.

TL;DR: Endothelin exerts potent constrictor effects on renal arterioles which precede its systemic hypertensive action and a potential role for this peptide is proposed in the control of mesangial cell function, glomerular filtration rate, and renal vascular tone.

TL;DR: These studies examine the in vivo formation of a unique series of PGF2-like compounds (F2-isoprostanes) derived from free radical-catalyzed nonenzymatic peroxidation of arachidonic acid to understand further the formation of these compounds in vivo.

TL;DR: 8-epi-PGF2 alpha probably exerts its biological actions in vascular smooth muscle through activation of receptor sites related to but distinct from TxA2 receptors, and the existence of such binding sites suggests novel avenues for investigation into the biology of TXA2 and of free radical-mediated tissue injury.

TL;DR: The studies indicate that acquired or inherited abnormalities in renal epoxygenase activities and/or regulation can be related to salt-sensitive hypertension in rodents and studies on the human renal ep oxygengenase and its relationship to salt hypertension may prove useful.