K
Kimberly A. Kelly
Researcher at University of Virginia
Publications - 93
Citations - 6162
Kimberly A. Kelly is an academic researcher from University of Virginia. The author has contributed to research in topics: Phage display & Pancreatic cancer. The author has an hindex of 34, co-authored 92 publications receiving 5745 citations. Previous affiliations of Kimberly A. Kelly include Hamilton College & University of California, Los Angeles.
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Journal ArticleDOI
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules.
TL;DR: Whether multivalent attachment of small molecules can increase specific binding affinity and reveal new biological properties of nanomaterials is investigated and a parallel synthesis of a library comprising 146 nanoparticles decorated with different synthetic small molecules is described.
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Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis
Matthias Nahrendorf,Farouc A. Jaffer,Kimberly A. Kelly,David E. Sosnovik,Elena Aikawa,Peter Libby,Ralph Weissleder +6 more
TL;DR: VINP-28 allows noninvasive imaging of VCAM-1–expressing endothelial cells and macrophages in atherosclerosis and spatial monitoring of anti-VCAM- 1 pharmacotherapy in vivo and identifies inflammatory cells in human atheromata, suggesting this clinically translatable agent could noninvasively detect inflammation in early, subclinical Atherosclerosis.
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Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
Kimberly A. Kelly,Jennifer R. Allport,Andrew Tsourkas,Vivek R. Shinde-Patil,Lee Josephson,Ralph Weissleder +5 more
TL;DR: Small peptide sequences can significantly alter targeting of NPs, the used amplification strategy of internalization results in high target-to-background ratios, and this technology is useful for in vivo imaging of endothelial markers.
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M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer
Debadyuti Ghosh,Youjin Lee,Stephanie Thomas,Aditya G. Kohli,Dong Soo Yun,Angela M. Belcher,Kimberly A. Kelly +6 more
TL;DR: In this article, a M13 filamentous bacteriophage was used as a scaffold to display targeting ligands and multiple nanoparticles for magnetic resonance imaging of cancer cells and tumours in mice.
Journal ArticleDOI
Targeted delivery of multifunctional magnetic nanoparticles.
TL;DR: Next-generation magnetic nanoparticles are expected to be truly multifunctional, incorporating therapeutic functionalities and further enhancing an already diverse repertoire of capabilities.