K
Kimikazu Hashino
Publications - 2
Citations - 810
Kimikazu Hashino is an academic researcher. The author has contributed to research in topics: Haematopoiesis & CD34. The author has an hindex of 2, co-authored 2 publications receiving 798 citations.
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Journal ArticleDOI
Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells.
Helmut Hanenberg,Xiang Li Xiao,Dagmar Dilloo,Kimikazu Hashino,Ikunoshin Kato,David R. Williams +5 more
TL;DR: It is demonstrated that enhanced gene transfer into mammalian target cells is due to direct binding of retroviral particles to sequences within the fibronectin molecule.
Journal ArticleDOI
Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells.
Helmut Hanenberg,Kimikazu Hashino,Haruko Konishi,Randy A. Hock,Ikunoshin Kato,David A. Williams +5 more
TL;DR: A simple and short clinically applicable transduction protocol that targets up to 68% of BM or G-CSF-mobilized PBCD34+ cells and is capable of genetically modifying up to 17% of CD34+CD38-/dim PB cells is established.