Institution
Riley Hospital for Children
Healthcare•Indianapolis, Indiana, United States•
About: Riley Hospital for Children is a healthcare organization based out in Indianapolis, Indiana, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 1448 authors who have published 1731 publications receiving 49242 citations. The organization is also known as: Riley Hospital for Children & James Whitcomb Riley Hospital for Children.
Topics: Population, Medicine, Transplantation, Poison control, Bone marrow
Papers published on a yearly basis
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TL;DR: Gene targeting was used to generate mice with a null allele of the gene involved in X–linked CGD, which encodes the 91 kD subunit of the oxidase cytochrome b, and affected hemizygous male mice lacked phagocyte superoxide production and had an altered inflammatory response in thioglycollate peritonitis.
Abstract: Chronic granulomatous disease (CGD) is a recessive disorder characterized by a defective phagocyte respiratory burst oxidase, life-threatening pyogenic infections and inflammatory granulomas. Gene targeting was used to generate mice with a null allele of the gene involved in X-linked CGD, which encodes the 91 kD subunit of the oxidase cytochrome b. Affected hemizygous male mice lacked phagocyte superoxide production, manifested an increased susceptibility to infection with Staphylococcus aureus and Aspergillus fumigatus and had an altered inflammatory response in thioglycollate peritonitis. This animal model should aid in developing new treatments for CGD and in evaluating the role of phagocyte-derived oxidants in inflammation.
872 citations
TL;DR: This white paper details a proposed action plan for the college derived from the deliberations of the ACR Blue Ribbon Panel on Radiation Dose in Medicine and reflects the findings of that panel.
Abstract: The benefits of diagnostic imaging are immense and have revolutionized the practice of medicine. The increased sophistication and clinical efficacy of imaging have resulted in its dramatic growth over the past quarter century. Although data derived from the atomic bomb survivors in Japan and other events suggest that the expanding use of imaging modalities using ionizing radiation may eventually result in an increased incidence of cancer in the exposed population, this problem can likely be minimized by preventing the inappropriate use of such imaging and by optimizing studies that are performed to obtain the best image quality with the lowest radiation dose. The ACR, which has been an advocate for radiation safety since its inception in 1924, convened the ACR Blue Ribbon Panel on Radiation Dose in Medicine to address these issues. This white paper details a proposed action plan for the college derived from the deliberations of that panel.
862 citations
University of Pittsburgh1, Riley Hospital for Children2, Washington University in St. Louis3, Baylor College of Medicine4, Texas Tech University5, Northwestern University6, University of British Columbia7, Medical College of Wisconsin8, Saint Barnabas Medical Center9, University of Pennsylvania10, University College London11, University of Alberta12, Duke University13, McMaster University14, Yeshiva University15, University of Michigan16, Laval University17, Kaiser Permanente18, Emory University19, University of Maryland, Baltimore20, Cornell University21, Nationwide Children's Hospital22, Children's Mercy Hospital23, Texas Tech University Health Sciences Center at El Paso24, University of Florida25, St Mary's Hospital26, University of Rochester27, University of Washington28, Stanford University29, University of California, San Diego30, Valley Hospital31, University of Melbourne32, Royal Children's Hospital33, Loma Linda University34, Great Ormond Street Hospital35, Boston Children's Hospital36, Austral University37, University of Colorado Denver38, Nemours Foundation39
TL;DR: A major new recommendation in the 2014 update of the 2007 American College of Critical Care Medicine “Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock” is consideration of institution—specific use of a recognition bundle containing a trigger tool for rapid identification of patients with septic shock.
Abstract: Objectives:The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock Provide the 2014 update of the 2007 American College of Critical Care Medicine “Clinical Guidelines for Hemodynamic Support of Neonates and Child
605 citations
TL;DR: Enzyme replacement therapy prevents progressive manifestations of Gaucher disease, and ameliorates Gaucher Disease-associated anemia, thrombocytopenia, organomegaly, bone pain, and bone crises.
529 citations
TL;DR: Cardiac anomalies and ultrashort-bowel syndrome requiring long-term total parenteral nutrition, which can be complicated by liver disease, are the major causes of morbidity and mortality in infants with intestinal atresia.
Abstract: Objective To evaluate the causes, clinical presentation, diagnosis, operative management, postoperative care, and outcome in infants with intestinal atresia. Design Retrospective case series. Setting Pediatric tertiary care teaching hospital. Patients A population-based sample of 277 neonates with intestinal atresia and stenosis treated from July 1, 1972, through April 30, 1997. The level of obstruction was duodenal in 138 infants, jejunoileal in 128, and colonic in 21. Of the 277 neonates, 10 had obstruction in more than 1 site. Duodenal atresia was associated with prematurity (46%), maternal polyhydramnios (33%), Down syndrome (24%), annular pancreas (33%), and malrotation (28%). Jejunoileal atresia was associated with intrauterine volvulus, (27%), gastroschisis (16%), and meconium ileus (11.7%). Interventions Patients with duodenal obstruction were treated by duodenoduodenostomy in 119 (86%), of 138 patients duodenotomy with web excision in 9 (7%), and duodenojejunostomy in 7 (5%) A duodenostomy tube was placed in 3 critically ill neonates. Patients with jejunoileal atresia were treated with resection in 97 (76%) of 128 patients (anastomosis, 45 [46]; tapering enteroplasty, 23 [24]; or temporary ostomy, 29 [30]), ostomy alone in 25 (20%), web excision in 5 (4%), and the Bianchi procedure in 1(0.8%). Patients with colon atresia were managed with initial ostomy and delayed anastomosis in 18 (86%) of 21 patients and resection with primary anastomosis in 3 (14%). Short-bowel syndrome was noted in 32 neonates. Main Outcome Measures Morbidity and early and late mortality. Results Operative mortality for neonates with duodenal atresia was 4%, with jejunoileal atresia, 0.8%, and with colonic atresia, 0%. The long-term survival rate for children with duodenal atresia was 86%; with jejunoileal atresia, 84%; and with colon atresia, 100%. The Bianchi procedure (1 patient, 0.8%) and growth hormone, glutamine, and modified diet (4 patients, 1%) reduced total parenteral nutrition dependence. Conclusions Cardiac anomalies (with duodenal atresia) and ultrashort-bowel syndrome (
476 citations
Authors
Showing all 1458 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| David R. Williams | 178 | 2034 | 138789 |
| Tim J Cole | 136 | 827 | 92998 |
| David A. Williams | 106 | 633 | 42058 |
| Christopher J. McDougle | 92 | 387 | 29180 |
| Mark Krailo | 85 | 394 | 22772 |
| Stuart Sherman | 83 | 658 | 25070 |
| Alan D. Rogol | 81 | 461 | 24865 |
| William A. Baumgartner | 77 | 391 | 18392 |
| Mary C. Dinauer | 76 | 221 | 19453 |
| Maria Tsokos | 75 | 329 | 18599 |
| Wendy B. London | 73 | 296 | 20608 |
| Elizabeth J. Perlman | 72 | 260 | 16621 |
| Lemuel A. Moyé | 71 | 227 | 36951 |
| Susan L. Cohn | 71 | 268 | 16726 |
| Mark H. Kaplan | 67 | 300 | 17604 |