K
Kirill Nemirov
Researcher at Pasteur Institute
Publications - 5
Citations - 119
Kirill Nemirov is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Viral vector & Vaccination. The author has an hindex of 3, co-authored 5 publications receiving 28 citations.
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Journal ArticleDOI
Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models.
Min Wen Ku,Maryline Bourgine,Pierre Authié,Jodie Lopez,Kirill Nemirov,Fanny Moncoq,Amandine Noirat,Benjamin Vesin,Fabien Nevo,Catherine Blanc,Philippe Souque,Houda Tabbal,Emeline Simon,David Hardy,Marine Le Dudal,Françoise Guinet,Laurence Fiette,Hugo Mouquet,François Anna,Annette Martin,Nicolas Escriou,Laleh Majlessi,Pierre Charneau +22 more
TL;DR: These results provide evidence of marked prophylactic effects of the LV-based vaccination against SARS-CoV-2 and designate intranasal immunization as a powerful approach against COVID-19.
Journal ArticleDOI
Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.
Min-Wen Ku,Pierre Authié,Maryline Bourgine,François Anna,Amandine Noirat,Fanny Moncoq,Benjamin Vesin,Fabien Nevo,Jodie Lopez,Philippe Souque,Catherine Blanc,Ingrid Fert,Sébastien Chardenoux,llta Lafosse,Delphine Cussigh,David Hardy,Kirill Nemirov,Françoise Guinet,Francina Langa Vives,Laleh Majlessi,Pierre Charneau +20 more
TL;DR: In this paper, a transgenic mouse strain expressing the human angiotensin-converting enzyme 2 was generated, and the brain permissiveness to SARS-CoV-2 replication was shown to be high in the lung.
Posted ContentDOI
Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical Models
Min-Wen Ku,Maryline Bourgine,Pierre Authié,Jodie Lopez,Kirill Nemirov,Fanny Moncoq,Amandine Noirat,Benjamin Vesin,Fabien Nevo,Catherine Blanc,Philippe Souque,Tabbal H,Simon E,Le Dudal M,Françoise Guinet,Laurence Fiette,Hugo Mouquet,François Anna,Annette Martin,Nicolas Escriou,Laleh Majlessi,Pierre Charneau +21 more
TL;DR: The results provide evidence of marked prophylactic effects of the LV-based vaccination against SARS-CoV-2 and designate the intranasal immunization as a powerful approach against COVID-19.
Posted ContentDOI
Intranasal Immunization with a Lentiviral Vector Coding for SARS-CoV-2 Spike Protein Confers Vigorous Protection in Pre-Clinical Animal Models
Min-Wen Ku,Maryline Bourgine,Pierre Authié,Jodie Lopez,Kirill Nemirov,Fanny Moncoq,Amandine Noirat,Benjamin Vesin,Fabien Nevo,Catherine Blanc,Philippe Souque,Houda Tabbal,Emeline Simon,Marine Le Dudal,Françoise Guinet,Laurence Fiette,Hugo Mouquet,François Anna,Annette Martin,Nicolas Escriou,Laleh Majlessi,Pierre Charneau +21 more
TL;DR: The results provide the proof-of-principle evidence of marked prophylactic effects of an LV-based vaccination strategy against SARS-CoV-2 in two pre-clinical animal models and designate the intranasal LV::SFL-based immunization as a vigorous and promising vaccine approach against COVID-19.
Posted ContentDOI
Full Brain and Lung Prophylaxis against SARS-CoV-2 by Intranasal Lentiviral Vaccination in a New hACE2 Transgenic Mouse Model or Golden Hamsters
Min-Wen Ku,Pierre Authié,Maryline Bourgine,François Anna,Amandine Noirat,Fanny Moncoq,Benjamin Vesin,Fabien Nevo,Jodie Lopez,Philippe Souque,Catherine Blanc,Sébastien Chardenoux,Ilta Lafosse,David Hardy,Kirill Nemirov,Françoise Guinet,Francina Langa Vives,Laleh Majlessi,Pierre Charneau +18 more
TL;DR: In this article, a single intranasal administration of a lentiviral vector encoding a prefusion form of SARS-CoV-2 spike glycoprotein induces full protection of respiratory tracts and totally avoids pulmonary inflammation in the susceptible hamster model.