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Amandine Noirat
Researcher at Pasteur Institute
Publications - 12
Citations - 138
Amandine Noirat is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 5 publications receiving 28 citations.
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Journal ArticleDOI
Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models.
Min Wen Ku,Maryline Bourgine,Pierre Authié,Jodie Lopez,Kirill Nemirov,Fanny Moncoq,Amandine Noirat,Benjamin Vesin,Fabien Nevo,Catherine Blanc,Philippe Souque,Houda Tabbal,Emeline Simon,David Hardy,Marine Le Dudal,Françoise Guinet,Laurence Fiette,Hugo Mouquet,François Anna,Annette Martin,Nicolas Escriou,Laleh Majlessi,Pierre Charneau +22 more
TL;DR: These results provide evidence of marked prophylactic effects of the LV-based vaccination against SARS-CoV-2 and designate intranasal immunization as a powerful approach against COVID-19.
Journal ArticleDOI
Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.
Min-Wen Ku,Pierre Authié,Maryline Bourgine,François Anna,Amandine Noirat,Fanny Moncoq,Benjamin Vesin,Fabien Nevo,Jodie Lopez,Philippe Souque,Catherine Blanc,Ingrid Fert,Sébastien Chardenoux,llta Lafosse,Delphine Cussigh,David Hardy,Kirill Nemirov,Françoise Guinet,Francina Langa Vives,Laleh Majlessi,Pierre Charneau +20 more
TL;DR: In this paper, a transgenic mouse strain expressing the human angiotensin-converting enzyme 2 was generated, and the brain permissiveness to SARS-CoV-2 replication was shown to be high in the lung.
Journal ArticleDOI
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa
Benjamin Vesin,Jodie Lopez,Amandine Noirat,Pierre Authié,Ingrid Fert,Fabien Le Chevalier,Fanny Moncoq,Kirill Nemirov,Catherine Blanc,Cyril Planchais,Hugo Mouquet,François Gouin,David Hardy,Francina Langa Vives,Christiane Gerke,François Anna,Maryline Bourgine,Laleh Majlessi,Pierre Charneau +18 more
TL;DR: In this article , an optimized cross-protective intranasal booster against COVID-19 was proposed using the lentiviral vaccination vector (LV), which is particularly suitable for this route of immunization owing to its non-cytopathic, non-replicative and scarcely inflammatory properties.
Posted ContentDOI
Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical Models
Min-Wen Ku,Maryline Bourgine,Pierre Authié,Jodie Lopez,Kirill Nemirov,Fanny Moncoq,Amandine Noirat,Benjamin Vesin,Fabien Nevo,Catherine Blanc,Philippe Souque,Tabbal H,Simon E,Le Dudal M,Françoise Guinet,Laurence Fiette,Hugo Mouquet,François Anna,Annette Martin,Nicolas Escriou,Laleh Majlessi,Pierre Charneau +21 more
TL;DR: The results provide evidence of marked prophylactic effects of the LV-based vaccination against SARS-CoV-2 and designate the intranasal immunization as a powerful approach against COVID-19.
Journal ArticleDOI
A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity.
Jodie Lopez,François Anna,Pierre Authié,Alexandre Pawlik,Min Wen Ku,Catherine Blanc,Philippe Souque,Fanny Moncoq,Amandine Noirat,David Hardy,Wladimir Sougakoff,Roland Brosch,François Gouin,Pierre Charneau,Laleh Majlessi +14 more
TL;DR: In this article , the authors devised a strategy whereby LV-encoded antigens are extended at their N-terminal end with the MHC-II-associated light invariant chain (li), which contains an endosome-targeting signal sequence.