K
Kit S. Lam
Researcher at University of California, Davis
Publications - 532
Citations - 23012
Kit S. Lam is an academic researcher from University of California, Davis. The author has contributed to research in topics: Peptide library & Peptide. The author has an hindex of 70, co-authored 509 publications receiving 20682 citations. Previous affiliations of Kit S. Lam include Central Connecticut State University & Technion – Israel Institute of Technology.
Papers
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Journal ArticleDOI
A new type of synthetic peptide library for identifying ligand-binding activity
Kit S. Lam,Sydney E. Salmon,Evan M. Hersh,Victor J. Hruby,Wieslaw M. Kazmierski,Richard J. Knapp +5 more
TL;DR: The simple methodology greatly enhances the production and rapid evaluation of random libraries of millions of peptides so that acceptor-binding ligands of high affinity can be rapidly identified and sequenced, on the basis of a "one-bead, one-peptide9 approach.
Journal ArticleDOI
The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles
Kai Xiao,Yuanpei Li,Juntao Luo,Joyce S Lee,Wenwu Xiao,Abby M. Gonik,Rinki G. Agarwal,Kit S. Lam +7 more
TL;DR: It is concluded that slightly negative charge may be introduced to the NPs surface to reduce the undesirable clearance by the reticuloendothelial system (RES) such as liver, improve the blood compatibility, thus deliver the anti-cancer drugs more efficiently to the tumor sites.
Journal ArticleDOI
The “One-Bead-One-Compound” Combinatorial Library Method
TL;DR: 1. Small Molecule Libraries 420 1. Acyclic Libraries 422 2. Libraries on Preformed Scaffolds 422 3. Heterocyclic Libraries 423 4. Structurally Heterogeneous Libraries 427 E. Cleavable Linkers 428 1. Single Cleavables 428 2. Multiply Cleavably Linkers 429 IV. Screening Methods 432
Journal ArticleDOI
Prospective Evaluation of Cancer Clinical Trial Accrual Patterns: Identifying Potential Barriers to Enrollment
Primo N. Lara,Roger Higdon,Nelson Lim,Karen Kwan,Michael Tanaka,Derick H Lau,Theodore Wun,Jeanna L Welborn,Frederick J. Meyers,Scott D Christensen,Robert T. O'Donnell,Carol M. Richman,Sidney A. Scudder,Joseph Tuscano,David R. Gandara,Kit S. Lam +15 more
TL;DR: Barriers to cancer clinical trial accrual can be prospectively identified and addressed in the development and conduct of future studies, which may potentially lead to more robust clinical trials enrollment.
Patent
Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
TL;DR: The instant invention as mentioned in this paper provides a library of bio-oligomers of defined size and known composition, in which the library contains all of the possible sequences of the bio-OLigomers, and a method of synthesis thereof.