Victor J. Hruby

TL;DR: The simple methodology greatly enhances the production and rapid evaluation of random libraries of millions of peptides so that acceptor-binding ligands of high affinity can be rapidly identified and sequenced, on the basis of a "one-bead, one-peptide9 approach.

TL;DR: The authors' data show that melanocortinergic neurons exert a tonic inhibition of feeding behaviour, and chronic disruption of this inhibitory signal is a likely explanation of the agouti obesity syndrome.

TL;DR: In this article, cyclic melanocortin analogues were identified that are potent agonists or antagonists of the neural MC3 and MC4 receptors, thus explaining the inhibitory effect of agouti on eumelanin pigment synthesis.

TL;DR: The conformationally restricted, cyclic, disulfide-containing, enkephalin analogs and the bis-Pen-containing analogs provide an order of magnitude increase in delta receptor selectivity.

TL;DR: This Nle4, D-Phe7 synthetic analogue of alpha-MSH is a very porent melanotropin, 26 times as potent as alpha- MSH in the adenylate cyclase assay, and the resistance of the peptide to enzymatic degradation and its extraordinarily potent and prolonged biological activity should make this analogue ofalpha-MSh an important molecular probe for studying the melanotropic receptors of both normal and abnormal (melanoma) melanocytes.