K
Kitae Lim
Researcher at OSI Pharmaceuticals
Publications - 6
Citations - 129
Kitae Lim is an academic researcher from OSI Pharmaceuticals. The author has contributed to research in topics: NS5B & Carboxamide. The author has an hindex of 5, co-authored 6 publications receiving 124 citations.
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Journal ArticleDOI
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site
Ariamala Gopalsamy,Rajiv Chopra,Kitae Lim,Gregory Ciszewski,Mengxiao Shi,Kevin J. Curran,Steven F. Sukits,Kristine Svenson,Joel Bard,John W. Ellingboe,Atul Agarwal,Girija Krishnamurthy,Anita Y. M. Howe,Mark Orlowski,Boris Feld,John O'Connell,Tarek S. Mansour +16 more
TL;DR: Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor and optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selectivity.
Journal ArticleDOI
Novel (4-Piperidin-1-yl)-phenyl Sulfonamides as Potent and Selective Human β3 Agonists
Baihua Hu,John W. Ellingboe,Stella Han,Elwood Largis,Kitae Lim,Michael S. Malamas,Ruth Mulvey,Chuansheng Niu,Alexander Oliphant,Jeffrey C. Pelletier,Thiruvikraman Singanallore,Fuk-Wah Sum,Jeff Tillett,Victoria Wong +13 more
TL;DR: N-Alkyl substitution on the 4-piperidin-1-yl-phenylamine further increased the beta(3) potency while maintaining the selectivity, and sulfonamide 48 is a potent full beta( 3) agonist with > 500-fold selectivity over beta(1)- and beta(2)-ARs.
Journal ArticleDOI
Design and syntheses of 1,6-naphthalene derivatives as selective HCMV protease inhibitors.
Ariamala Gopalsamy,Kitae Lim,John W. Ellingboe,Boris Mitsner,Antonia A. Nikitenko,Janis Upeslacis,Tarek S. Mansour,Matthew W. Olson,Geraldine Bebernitz,Diane Grinberg,Boris Feld,Franklin J. Moy,John O'Connell +12 more
TL;DR: Optimization of various regions of the lead molecule using parallel synthesis resulted in 1,6-substituted naphthalenes 19d-i, which displayed good potency and were selective over elastase, trypsin, and chymotrypsin.
Journal ArticleDOI
Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.
Ariamala Gopalsamy,Kitae Lim,John W. Ellingboe,Girija Krishnamurthy,Mark Orlowski,Boris Feld,Marja van Zeijl,Anita Y. M. Howe +7 more
TL;DR: Tetra substituted naphthalene 31 displayed potent activity with IC(50) of 120 nM against HCV NS5B enzyme and was selective over a panel of polymerases.
Journal ArticleDOI
Novel and selective calcitonin-inducing agents
Adam Matthew Gilbert,Stephen Caltabiano,Denise Roberts,Sam F. W. Sum,Gerardo D. Francisco,Kitae Lim,Magda Asselin,John W. Ellingboe,Yogendra Kharode,Anna Cannistraci,Rita Francis,Mark Trailsmith,David Gralnick +12 more
TL;DR: It is found that certain di-n-butylxanthine sulfonamides 4 upregulate CT transcription in a CT-luciferase reporter gene assay (CT-luci) and increase the production and release of CT in aCT secretion/RIA test (CTS), and these compounds do not have potent PDE4 inhibitory activity.