K
Kjell Svensson
Researcher at Eli Lilly and Company
Publications - 57
Citations - 2316
Kjell Svensson is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Agonist & Dopamine. The author has an hindex of 24, co-authored 57 publications receiving 2248 citations. Previous affiliations of Kjell Svensson include Upjohn & Pfizer.
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Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
TL;DR: In naive animals 8-OH-DPAT exerting anticonflict effects acted like a 5-HT antagonist, whereas in subchronically PCPA-pretreated animals with presumably supersensitive 5- HT receptors, 8- OH- DPAT decreasing the number of accepted shocks actedlike a 5,HT agonist.
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Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (–)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)
TL;DR: The data demonstrate that the antipsychotic-like effects of the mGlu2/3 receptor agonist LY404039 in psychostimulant models of psychosis are mechanistically distinct from those of atypical antipsychotics drugs and are dependent on functional mGLU2 and notmGlu3 receptors.
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Mesotelencephalic dopamine system and reproductive behavior in the female rat: effects of ventral tegmental 6-hydroxydopamine lesions on maternal and sexual responsiveness.
TL;DR: Rat dams that were given ventral tegmental area microinfusions of 6-hydroxydopamine during lactation showed a persistent deficit in pup retrieval but were not impaired with respect to nursing, nest building, or maternal aggression, while 6-OHDA-lesioned females failed to respond to amphetamine by showing locomotor hyperactivity.
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Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors
TL;DR: The hypothesis that the functional dopamine D3 receptor is a postsynaptic receptor inhibitory on rat locomotion is supported and the present data support the hypothesis.
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Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior
Gregory T. Collins,Jeffrey M. Witkin,Amy Hauck Newman,Kjell Svensson,Peter Grundt,Jianjing Cao,James H. Woods +6 more
TL;DR: It is reported that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve.