K
Klaus Bumm
Researcher at University of Erlangen-Nuremberg
Publications - 49
Citations - 1994
Klaus Bumm is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Antigen & Multiple myeloma. The author has an hindex of 18, co-authored 47 publications receiving 1912 citations. Previous affiliations of Klaus Bumm include University of Arkansas for Medical Sciences & Texas Tech University Health Sciences Center.
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Journal ArticleDOI
Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells
Fenghuang Zhan,Johanna Hardin,Bob Kordsmeier,Klaus Bumm,Mingzhong Zheng,Erming Tian,Ralph D. Sanderson,Yang Yang,Carla S. Wilson,Maurizio Zangari,Elias Anaissie,Christopher Morris,Firas Muwalla,Frits van Rhee,Athanasios Fassas,John Crowley,Guido Tricot,Bart Barlogie,John D. Shaughnessy +18 more
TL;DR: Novel candidate MM disease genes have been identified using gene expression profiling and this profiling has led to the development of a gene-based classification system for MM.
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High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH
John D. Shaughnessy,Erming Tian,Jeffrey R. Sawyer,Klaus Bumm,Reid D. Landes,Ashraf Badros,Christopher Morris,Guido Tricot,Joshua Epstein,Bart Barlogie +9 more
TL;DR: The absence of increasing deletion incidence and extent with therapy duration suggests that the observed lesions are not induced by treatment, and analyses will provide valuable guidance toward cloning of an MM-TSG.
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Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development
TL;DR: Genes whose expression is linked to distinct transitions in late-stage B-cell differentiation can be used to classify multiple myeloma with respect to the expression patterns of these genes.
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Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: interpretation in the context of global gene expression
John D. Shaughnessy,Joth Jacobson,Jeffrey R. Sawyer,Jason McCoy,Athanasios Fassas,Fenghuang Zhan,Klaus Bumm,Joshua Epstein,Elias Anaissie,Sundar Jagannath,David H. Vesole,David A. Siegel,Raman Desikan,Nikhil C. Munshi,Ashraf Badros,Erming Tian,Maurizio Zangari,Guido Tricot,John Crowley,Bart Barlogie +19 more
TL;DR: FISH 13, resulting in a haploinsufficiency of RB1 and other genes mapping to chromosome 13, as well as activation of IGF1R, appears to have an amplifying effect on cell cycle gene expression, thus providing a molecular explanation for the dire outcome of patients with CA 13 compared with those with other CAs.
Journal ArticleDOI
Sialoscopy in cases of unclear swelling of the major salivary glands.
TL;DR: In cases of invisible salivary duct obstruction, especially in those with low mineralized calculi, strictures, stenoses, or postinflammatory changes, sialoscopy gives immediate and direct information about causal pathologies.