K
Koichiro Asano
Researcher at Brigham and Women's Hospital
Publications - 9
Citations - 1406
Koichiro Asano is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Epidermal growth factor & Nitric oxide synthase. The author has an hindex of 8, co-authored 9 publications receiving 1394 citations.
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Journal ArticleDOI
Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells
Koichiro Asano,Cynthia B. E. Chee,Benjamin Gaston,Craig M. Lilly,Craig Gerard,Jeffrey M. Drazen,Jonathan S. Stamler +6 more
TL;DR: The coexistence of constitutive and inducible NOS in human alveolar and bronchial epithelium cells is consistent with a complex mechanism evolved by epithelial cells to protect the host from microbial assault at the air/surface interface while shielding thehost from the induction of airway hyperreactivity.
Journal ArticleDOI
Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation
Joan B. Mannick,Koichiro Asano,Kenneth M. Izumi,Kenneth M. Izumi,Elliott Kieff,Elliott Kieff,Jonathan S. Stamler +6 more
TL;DR: Constutive, low level, macrophage-type NO synthase (iNOS) expression in Epstein-Barr virus-transformed human B lymphocytes and Burkitt's lymphoma cell lines suggest that NO plays a physiological role in human B cell biology by inhibiting programmed cell death and maintaining viral latency.
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Diurnal variation of urinary leukotriene E4 and histamine excretion rates in normal subjects and patients with mild-to-moderate asthma.
Koichiro Asano,Craig M. Lilly,Walter J. O'Donnell,Elliot Israel,Andrew R. Fischer,Bernard J. Ransil,Jeffrey M. Drazen +6 more
TL;DR: Although no systematic variation in urinary LTE4 excretion rates over the course of a day was observed in either normal subjects or patients with stable asthma, the presence of a systematic diurnal variation of urinary histamine excretion exists in both groups.
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Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells
TL;DR: It is concluded that PGHS-2 is the dominant PGHS isoform in unstimulated and stimulated lung epithelial cells in culture.
Journal ArticleDOI
Acute and chronic effects of allergic airway inflammation on pulmonary nitric oxide production
Sanjay Mehta,Craig M. Lilly,J. E. Rollenhagen,Kathleen J. Haley,Koichiro Asano,Jeffrey M. Drazen +5 more
TL;DR: The hypothesis that endogenous pulmonary NO production, as reflected by expired NO, has an important homeostatic role in acute allergic bronchoconstriction is supported.