K
Koji Todaka
Researcher at Kyushu University
Publications - 47
Citations - 582
Koji Todaka is an academic researcher from Kyushu University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 38 publications receiving 493 citations. Previous affiliations of Koji Todaka include Nara Institute of Science and Technology & Columbia University.
Papers
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Journal ArticleDOI
Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial
Kiminori Kimura,Akemi Ikoma,Maki Shibakawa,Shinji Shimoda,Kenichi Harada,Masanao Saio,Jun Imamura,Yosuke Osawa,Masamichi Kimura,Koji Nishikawa,Takuji Okusaka,Satoshi Morita,Kazuaki Inoue,Tatsuya Kanto,Koji Todaka,Yoichi Nakanishi,Michinori Kohara,Masashi Mizokami +17 more
TL;DR: This study showed that administration of 10 or 40 mg/m2/day intravenous PRI-724 over 12 weeks was well-tolerated by patients with HCV cirrhosis; however, liver injury as a possible related serious adverse event was observed in the 160 mg/ m2/ day cohort.
Journal ArticleDOI
Dynamic effects of carotid sinus baroreflex on ventriculoarterial coupling studied in anesthetized dogs.
Toru Kubota,J. Alexander,Ryoichi Itaya,Koji Todaka,Masaru Sugimachi,Kenji Sunagawa,Yoshiaki Nose,Akira Takeshita +7 more
TL;DR: Because the arterial system extracts maximal external work from a given heart when Ea equals Ees, the carotid sinus baroreflex appeared to be designed to regulate the ventricular and arterial properties to optimize the energy transmission from the left ventricle to the arterials system in anesthetized, vagotomized dogs.
Journal Article
Effects of levosimendan on myocardial contractility and oxygen consumption.
Koji Todaka,Jie Wang,Geng Hua Yi,Richard Stennett,Mathias Knecht,Milton Packer,Daniel Burkhoff +6 more
TL;DR: The findings suggest that inotropic actions of levosimendan in vivo may be mediated in part by factors other than calcium sensitization, and it may be associated with a decreased energetic cost of inotropism in vivo.
Journal ArticleDOI
Effect of ventricular stretch on contractile strength, calcium transient, and cAMP in intact canine hearts
TL;DR: The findings of changes in cAMP and abolition of the phenomena by β-stimulation suggest that a primary stretch-mediated influence on cAMP metabolism may underlie these phenomena.
Journal ArticleDOI
A new method to identify dynamic transduction properties of aortic baroreceptors.
Masaru Sugimachi,Tsutomu Imaizumi,Kenji Sunagawa,Yoshitaka Hirooka,Koji Todaka,Akira Takeshita,Masafumi Nakamura +6 more
TL;DR: The white-noise technique made it possible to identify the unbiased linear properties in a nonlinear system, and thus was very useful in identifying complex biological systems.