PROBLEM TO BE SOLVED: To provide a vehicle rear structure having a simple configuration capable of restricting a reduction in the temperature of fuel gas. SOLUTION: A vehicle rear structure 10 is so constructed that both a pressure sensor 62 and a temperature sensor 6 constituting a gas-related auxiliary equipment 61 for a front compressed gas tank 40 and the rear compressed gas tank 41 are arranged at the left frame member 31 of a support frame 30; a high pressure filter 64, secondary regulator 65 and low pressure filter 66 constituting the gas-related auxiliary equipment 61 for the front compressed gas tank 40 and the rear compressed gas tank 41 are installed at the right frame member 32 of the support frame 30. Each of the gas-related auxiliary equipment 61 is connected to the front compressed gas tank 40 and the rear compressed gas tank 41 through a gas pipe unit 42. A gas supplying pipe 51 constituting the gas pipe unit 42 is contacted along the front cross member 33 of the support frame 30. COPYRIGHT: (C)2004,JPO

Vehicle rear structure

The invention provides a preparation method of an intermediate for synthesis of pilsicainide hydrochloride. The method comprises the following steps: step 1, performing a polymerization reaction on butyrolactam (I) and gamma-butyrolactone (II) under strong base and predetermined conditions to form N-(3-carboxypropyl)butyrolactam (III); step 2, performing cyclization on the N-(3-carboxypropyl)butyrolactam(III) at a high temperature in a monoisopropyl malonate solvent, performing condensation on the cyclization product and a monoester malonate to form 7alpha-pyrrolizine-acetate, wherein preferred choice is to produce 7alpha-pyrrolizine-isopropyl acetate (V); and step 3, performing hydrolysis on the 7alpha-pyrrolizine-acetate in an acid to form the corresponding pharmaceutically-acceptable salt. The preparation method provided by the invention avoids expensive or difficult-to-obtain raw materials, avoids use of liquid ammonia in the synthetic process, reduces the reaction steps, and has simple operation, less three waste (waste water, waste gas and solid waste) and a high yield.

Preparation method of intermediate of synthesis of pilsicainide hydrochloride

NEW MATERIAL:The compound of formula I (Ra and Rb are H, alkanoyl, alloyl, heteroalloyl, alkoxycarbonyl, aralkoxycarbonyl, aryloxycarbonyl, N- alkylcarbamoyl, N,N-dialkylcarbamoyl, N-aralkylcarbamoyl, alkoxyalkyl, etc.; Ra and Rb are not H at the same time). EXAMPLE:(d)-1'-Cyclohexylacetyl-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro [4H-1- benzopyran-4,4'-imidazolidine]-2-carboxamide. USE:A preventive and remedy for complications of diabetes. It is strongly absorbed and transferred into a tissue containing aldose reductase and exhibits the drug action. PREPARATION:The compound of formula I can be produced e.g., by reacting a compound of formula II with a compound of formula III (Rc is H, alkanoyl, etc.).

(d)-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro(4h-1-benzopyran-4,4'-imidazolidine)-2-carboxamide derivative, its production and use thereof

of EP03457127a-Nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine of the formula and salts thereof, as well as processes for the preparation of the compound and 7a-aminomethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine and salts thereof.

Pyrrolizine derivate and its manufacture

7a-Nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine of the formula ##STR1## and salts thereof, as well as processes for the preparation of the compound and 7a-aminomethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine and salts thereof

Pyrrolizine derivative and its manufacture

Hydantoin derivatives of the formula ##STR1## wherein Ra and Rb are same or different, each being hydrogen atom, alkanoyl, substituted or none-substituted aroyl, heteroaroyl, alkoxycarbonyl, substituted or none-substituted aralkoxycarbonyl, aryloxycarbonyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, substituted or none-substituted N-aralkylcarbamoyl, alkoxyalkyl, 1-(acyloxy)-alkyl, alkylmercapto, substituted or none-substituted arylmercapto, alkylsulfinyl, substituted or none-substituted arylsulfinyl, alkylsulfonyl or substituted or none-substituted arylsulfonyl, but both of Ra and Rb do not concurrently mean hydrogen atom, a process for the preparation of the derivatives, and use thereof as an agent for preventing and curing chronic complications due to diabetes.

(D)-6-fluoro-2,3-dihydro-2',5-dioxo-spiro[4H-1-benzopyran-4,4'-imidazolide]-2-carboxamide compounds

Hydantoin derivatives of formula (I), wherein Ra and Rb are same or different, each being hydrogen atom, alkanoyl, substituted or non-substituted aroyl, heteroaroyl, alkoxycarbonyl, substituted or non-substituted aralkoxycarbonyl, aryloxycarbonyl, N-alkylcarbomoyl, N,N-dialkylcarbamoyl, substituted or non-substituted N-aralkylcarbamoyl, alkoxyalkyl, 1-(acyloxy)alkyl, alkylmercapto, substituted or non-substituted arylmercapto, alkylsulfinyl, substituted or non-substituted arylsulfinyl, alkylsulfonyl or substituted or non-substituted arylsulfonyl, but both of Ra and Rb do not concurrently mean hydrogen atom, a process for the preparation of the derivatives, and use thereof as an agent for preventing and curing chronic complications due to diabetes.

Kondo Yasuaki

Papers

(d)-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro(4h-1-benzopyran-4,4'-imidazolidine)-2-carboxamide derivative, its production and use thereof

Pyrrolizine derivate and its manufacture

Pyrrolizine derivative and its manufacture

(D)-6-fluoro-2,3-dihydro-2',5-dioxo-spiro[4H-1-benzopyran-4,4'-imidazolide]-2-carboxamide compounds

(d)-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro(4h-1-benzopyran-4,4'-imidazolidine)-2-carboxamide derivatives, manufacturing process and use thereof