K
Krassimira A. Rozenova
Researcher at University of Kentucky
Publications - 8
Citations - 363
Krassimira A. Rozenova is an academic researcher from University of Kentucky. The author has contributed to research in topics: Ceramide & Medicine. The author has an hindex of 4, co-authored 4 publications receiving 312 citations.
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Book ChapterDOI
Ceramide in stress response.
TL;DR: Findings are described in the context of several physiological and pathophysiological conditions, namely septic shock, obesity-induced insulin resistance, aging and apoptosis of tumor cells in response to radiation and chemotherapy.
Journal ArticleDOI
Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: Implications for endothelial apoptosis
Sabapathi Sathishkumar,Boris B. Boyanovsky,Alexander A. Karakashian,Krassimira A. Rozenova,Natalia V. Giltiay,Mahesh Kudrimoti,Mohammed Mohiuddin,Mansoor M. Ahmed,Mariana Nikolova-Karakashian +8 more
TL;DR: Serum S-SMase activity and ceramide content increase following SFGRT and correlate with the clinical response, and apparently, these changes are in the LDL-associated ceramide and may contribute to better tumor reduction after SF GRT, due to the ability of LDL–derived ceramide to sensitize endothelial cells for apoptosis.
Journal ArticleDOI
Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice
Gergana M. Deevska,Krassimira A. Rozenova,Natalia V. Giltiay,Melissa A. Chambers,James White,Boris B. Boyanovsky,Jia Wei,Alan Daugherty,Eric J. Smart,Michael B. Reid,Alfred H. Merrill,Mariana Nikolova-Karakashian +11 more
TL;DR: Evidence is provided that acid sphingomyelinase activity plays an essential role in the regulation of glucose metabolism by regulating the hepatic accumulation of triacylglycerides and sphingolipids during consumption of a diet rich in saturated fats.
Journal ArticleDOI
Studies on the Role of Acid Sphingomyelinase and Ceramide in the Regulation of Tumor Necrosis Factor α (TNFα)-converting Enzyme Activity and TNFα Secretion in Macrophages
Krassimira A. Rozenova,Gergana M. Deevska,Alexander A. Karakashian,Mariana Nikolova-Karakashian +3 more
TL;DR: This study shows that ASMase is a negative regulator of LPS-induced tumor necrosis factor α (TNFα) secretion in macrophages, and the underlying mechanism for these effects is not transcriptional but post-translational.
Journal ArticleDOI
Nonhealing Ulcer at a Surgical Site.
TL;DR: In this paper , a man in his 80s was evaluated for a 4.5 cm necrotic ulcer with a violaceous border at a previous surgical site and the nonhealing ulcer despite treatment was concerning for squamous cell carcinoma (Marjolin ulcer).