K
Krishna K. Murthi
Researcher at GPC Biotech
Publications - 34
Citations - 829
Krishna K. Murthi is an academic researcher from GPC Biotech. The author has contributed to research in topics: Cyclin-dependent kinase & Kinase. The author has an hindex of 17, co-authored 34 publications receiving 817 citations. Previous affiliations of Krishna K. Murthi include DuPont & Florida State University.
Papers
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Journal ArticleDOI
A Three-Hybrid Approach to Scanning the Proteome for Targets of Small Molecule Kinase Inhibitors
Frank Becker,Krishna K. Murthi,Chase C. Smith,Jon Come,Nuria Costa-Roldán,Christine Kaufmann,Urs Hanke,Carsten Degenhart,Sabine Baumann,Wolfgang Wallner,Andrea Huber,Severine Dedier,Simone Dill,David Kinsman,Mark Hediger,Nicholas Bockovich,Sebastian Meier-Ewert,Arthur F. Kluge,Nikolai Kley +18 more
TL;DR: The Y3H system described here may prove generally useful in the discovery of candidate drug targets in scanning the proteome for targets of kinase inhibitors.
Patent
Inhibitors of cyclin dependent kinases
TL;DR: In this article, the authors proposed novel inhibitors of cyclin-dependent kinases, in particular inhibitors of the CDK/cyclin complexes such as CDK4/cycle D1, which can be used for inhibiting excessive or abnormal cell proliferation.
Journal ArticleDOI
MASPIT: Three-Hybrid Trap for Quantitative Proteome Fingerprinting of Small Molecule-Protein Interactions in Mammalian Cells
Maureen Caligiuri,Lisa Molz,Qing Liu,Faith Kaplan,Jimmy P. Xu,Jiangwen Z. Majeti,Rebeca Ramos-Kelsey,Krishna K. Murthi,Sam Lievens,Jan Tavernier,Nikolai Kley +10 more
TL;DR: During the course of this study, the pyrido[2,3-d]pyrimidine PD173955, a known SRC kinase inhibitor, was identified as a potent inhibitor of several ephrin receptor tyrosine kinases, which could perhaps be exploited in the design of inhibitors for this kinase subfamily.
Journal ArticleDOI
Formation of DNA-protein cross-links in mammalian cells by levuglandin E2.
TL;DR: The results suggest that LG adducts to DNA or protein are not repaired, but react further at sites on protein or DNA in close proximity to the initial adduction, forming cross-links in a slow phase of the process.
Journal ArticleDOI
Structure–activity relationship studies of flavopiridol analogues
Krishna K. Murthi,Marja Dubay,Christopher McClure,Leonardo Brizuela,Michael D. Boisclair,Peter J. Worland,Muzammil M. Mansuri,Kollol Pal +7 more
TL;DR: Modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity are reported.