K
Krista A. Mitchnick
Researcher at University of Guelph
Publications - 13
Citations - 151
Krista A. Mitchnick is an academic researcher from University of Guelph. The author has contributed to research in topics: Perirhinal cortex & Medicine. The author has an hindex of 6, co-authored 10 publications receiving 106 citations.
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Journal ArticleDOI
Differential contributions of de novo and maintenance DNA methyltransferases to object memory processing in the rat hippocampus and perirhinal cortex – a double dissociation
Krista A. Mitchnick,Samantha D. Creighton,Matthew O'Hara,Bettina E. Kalisch,Boyer D. Winters +4 more
TL;DR: Results reinforce the established functional double dissociation between the HPC and PRh and imply the operation of different epigenetic mechanisms in brain regions dedicated to long‐term memory processing for different types of information.
Journal ArticleDOI
Cholinergic manipulations bidirectionally regulate object memory destabilization.
Mikaela L. Stiver,Derek L. Jacklin,Krista A. Mitchnick,Nevena Vicic,Justine Carlin,Matthew O'Hara,Boyer D. Winters +6 more
TL;DR: The effects of cholinergic manipulations in rats using an object recognition paradigm that requires reactivation novelty to destabilize object memories suggest a hitherto unappreciated mnemonic role for ACh with implications for its potential involvement in cognitive flexibility and the dynamic process of long-term memory storage.
Journal ArticleDOI
Dissociable involvement of estrogen receptors in perirhinal cortex-mediated object-place memory in male rats.
Krista A. Mitchnick,Ari L. Mendell,Cassidy E. Wideman,Kristen H. Jardine,Samantha D. Creighton,Anne-Marie Muller,Elena Choleris,Neil J. MacLusky,Boyer D. Winters +8 more
TL;DR: Assessment of the role of 17-βestradiol (E2), ERα, ERβ, GPER, and their downstream signaling pathways, in PRh-mediated object-in-place (OiP) memory in gonadally-intact male rats reveals interesting dissociations between the roles of various ERs.
Journal ArticleDOI
Dissociable roles for histone acetyltransferases p300 and PCAF in hippocampus and perirhinal cortex-mediated object memory.
Krista A. Mitchnick,Samantha D. Creighton,Jacob M. Cloke,Michael Wolter,O. Zaika,B. Christen,M. Van Tiggelen,Bettina E. Kalisch,Boyer D. Winters +8 more
TL;DR: Results demonstrate, for the first time, the necessity of histone acetyltransferase activity for PRh‐mediated object memory and indicate that the specific mnemonic roles of distinctive histoneacetyltransferases can be dissociated according to specific brain regions and memory timeframe.
Journal ArticleDOI
Activation of cortical M 1 muscarinic receptors and related intracellular signaling is necessary for reactivation-induced object memory updating
Kristen H. Jardine,Cassidy E. Wideman,Chelsea MacGregor,Cassandra Sgarbossa,Dean Orr,Krista A. Mitchnick,Boyer D. Winters +6 more
TL;DR: A hitherto unacknowledged cognitive function for acetylcholine is demonstrated with important implications for understanding the dynamic nature of long-term memory storage in the normal and aging brain.