K
Kristin Carner
Publications - 2
Citations - 2294
Kristin Carner is an academic researcher. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 2, co-authored 2 publications receiving 2248 citations.
Papers
More filters
Journal ArticleDOI
Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20
Reff Mitchell E,Kristin Carner,Karen S. Chambers,Paul Chinn,John E Leonard,Ron Raab,Roland A. Newman,Nabil Hanna,Darrell R Anderson +8 more
TL;DR: In vitro studies showed the ability of C2B8 to bind human C1q, mediate complement-dependent cell lysis of human B-lymphoid cell lines, and lyse human target cells through antibody-dependent cellular cytotoxicity and the possibility of using an "immunologically active" chimeric anti-CD20 antibody as an alternative approach in the treatment of B-cell lymphoma.
Journal ArticleDOI
"Primatization" of recombinant antibodies for immunotherapy of human diseases: a macaque/human chimeric antibody against human CD4.
Roland A. Newman,James Alberts,Darrell R Anderson,Kristin Carner,Heard Cheryl Janne,Frank Norton,Ron Raab,Reff Mitchell E,Steve Shuey,Nabil Hanna +9 more
TL;DR: It is shown that cynomolgus macaques are phylogenetically distant enough to respond against conserved human antigens, and a human/monkey chimeric anti-CD4 antibody with an apparent affinity of 3.2 × 10−11 M and exhibits potent immunosuppressive properties in vitro.