K
Kristin E. Rosner
Researcher at Merck & Co.
Publications - 22
Citations - 522
Kristin E. Rosner is an academic researcher from Merck & Co.. The author has contributed to research in topics: Hydantoin & Hepatitis C virus. The author has an hindex of 13, co-authored 22 publications receiving 481 citations. Previous affiliations of Kristin E. Rosner include Schering-Plough.
Papers
More filters
Journal ArticleDOI
An affinity selection–mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase
D. Allen Annis,John Athanasopoulos,Patrick J. Curran,Jason S. Felsch,Krishna Kalghatgi,William H. Lee,Huw M. Nash,Jean Paul A. Orminati,Kristin E. Rosner,Gerald W. Shipps,G. R.A. Thaddupathy,Andrew N. Tyler,Lev Vilenchik,Carston R. Wagner,Edward A. Wintner +14 more
TL;DR: The ALIS method requires no foreknowledge of the structure or biochemistry of the protein target, consumes less than 1 μg protein to screen >2500 compounds in a single experiment, and enables screening of >250,000 compounds per system per day.
Patent
Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
Gerald W. Shipps,Kristin E. Rosner,Janeta Popovici-Muller,Yongqi Deng,Tong Wang,Patrick J. Curran +5 more
TL;DR: In this article, the authors present compounds and methods for inhibiting RNA-dependent RNA polymerase enzymatic activity for hepatitis C virus (HCV) replication, as well as compositions for the prophylaxis and treatment of HCV infection.
Patent
Chemical compounds and pharmaceutical compositions containing them for the treatment of inflammatory disorders
Zhuyan Guo,Peter Orth,Zhaoning Zhu,Robert Mazzola,Chan Tin Yau,Vaccaro Henry A,Mckittrick Brian A,Joseph A. Kozlowski,Brian J. Lavey,Guowei Zhou,Sunil Paliwal,Shing-Chun Wong,Neng-Yang Shih,Pauline C. Ting,Kristin E. Rosner,Gerald W. Shipps,M. Arshad Siddiqui,David B. Belanger,Chaoyang Dai,Dansu Li,Vinay Girijavallabhan,Janeta Popovici-Muller,Wensheng Yu,Lianyun Zhao +23 more
TL;DR: In this article, the authors describe compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
Journal ArticleDOI
Discovery and SAR of hydantoin TACE inhibitors
Wensheng Yu,Zhuyan Guo,Peter Orth,Vincent S. Madison,Lei Chen,Chaoyang Dai,Feltz Robert,Vinay Girijavallabhan,Seong Heon Kim,Joseph A. Kozlowski,Brian J. Lavey,Dansu Li,Daniel Lundell,Xiaoda Niu,John J. Piwinski,Janeta Popovici-Muller,Razia Rizvi,Kristin E. Rosner,Bandarpalle B. Shankar,Neng-Yang Shih,M. Arshad Siddiqui,Jing Sun,Ling Tong,Shelby Umland,Wong Michael K C,De-Yi Yang,Guowei Zhou +26 more
TL;DR: Crystal structures of inhibitors bound to TACE revealed monodentate coordination of the hydantoin to the zinc, the first reported X-ray structures of TACE with aHydantoin zinc ligand.
Journal ArticleDOI
Biaryl substituted hydantoin compounds as TACE inhibitors
Wensheng Yu,Ling Tong,Seong Heon Kim,Wong Michael K C,Lei Chen,De-Yi Yang,Bandarpalle B. Shankar,Brian J. Lavey,Guowei Zhou,Aneta Kosinski,Razia Rizvi,Dansu Li,Feltz Robert,John J. Piwinski,Kristin E. Rosner,Neng-Yang Shih,M. Arshad Siddiqui,Zhuyan Guo,Peter Orth,Himanshu Shah,Jing Sun,Shelby Umland,Daniel Lundell,Xiaoda Niu,Joseph A. Kozlowski +24 more
TL;DR: A series of biaryl substituted hydantoin compounds was shown to have sub-nanomolar K(i), good rat PK, and good selectivity versus MMP-1, -2, -3, -7, -9, and -13.