Showing papers by "Kristin L. Nichol published in 1991"
Journal Article•
TL;DR: There was no significant difference between influenza vaccine and placebo with respect to the proportion of subjects reporting disability or systemic symptoms and a randomized, double-blind, crossover trial to compare the frequency of adverse reactions following administration of 1988-1989 trivalent split-antigen influenza vaccine.
Abstract: Concern about side effects constitutes a major deterrent to patient compliance with influenza vaccination, yet there is a paucity of data about the occurrence of adverse reactions in the population targeted for immunization. We conducted a randomized, double-blind, crossover trial to compare the frequency of adverse reactions following administration of 1988-1989 trivalent split-antigen influenza vaccine and saline placebo. Outpatient veterans 65 years of age or over (n = 336) were recruited by mail and were randomly assigned to receive vaccine followed 2 weeks later by placebo injection or placebo followed 2 weeks later by vaccine. There was no significant difference between influenza vaccine and placebo with respect to the proportion of subjects reporting disability or systemic symptoms. ( JAMA . 1990;264:1139-1141)
175 citations
TL;DR: A self-administered postcard questionnaire is a valid tool for estimating outpatient risk characteristics and influenza vaccination rates and demonstrates the importance of sample frame definition and response wave on estimates ofrisk characteristics and vaccination rates.
84 citations
TL;DR: An outpatient "flu shot" program that emphasizes administrative and organizational elements can be successfully expanded to high-risk inpatients and the vaccination rates attained may not only achieve but exceed the national health objective for influenza vaccination.
42 citations
TL;DR: It is concluded that positive anti-Legionella antibodies are a frequent occurrence among outpatients and has important implications for the interpretation of single or static antibody titers from patients who are acutely ill.
18 citations