K
Kristin M. West
Researcher at Johns Hopkins University
Publications - 2
Citations - 2481
Kristin M. West is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Gene silencing & Chromatin immunoprecipitation. The author has an hindex of 2, co-authored 2 publications receiving 2423 citations.
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Widespread microRNA repression by Myc contributes to tumorigenesis.
Tsung Cheng Chang,Duonan Yu,Yun-Sil Lee,Erik A. Wentzel,Dan E. Arking,Kristin M. West,Chi V. Dang,Andrei Thomas-Tikhonenko,Joshua T. Mendell +8 more
TL;DR: In this paper, the c-Myc oncogenic transcription factor (Myc) is pathologically activated in many human malignancies and the predominant consequence of activation of Myc is widespread repression of miRNA expression.
Journal Article
Widespread microRNA repression by Myc contributes to tumorigenesis
Tsung Cheng Chang,Duonan Yu,Yun-Sil Lee,Erik A. Wentzel,Dan E. Arking,Kristin M. West,Chi V. Dang,Andrei Thomas-Tikhonenko,Joshua T. Mendell +8 more
TL;DR: It is shown here that Myc regulates a much broader set of miRNAs than previously anticipated, and extensive reprogramming of the miRNA transcriptome by Myc contributes to tumorigenesis.