C
Chi V. Dang
Researcher at University of Pennsylvania
Publications - 283
Citations - 65273
Chi V. Dang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Transcription factor & Carcinogenesis. The author has an hindex of 103, co-authored 277 publications receiving 58824 citations. Previous affiliations of Chi V. Dang include University of California, San Diego & Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.
c-MYC-regulated micro RNAs modulate E2F1 expression
TL;DR: In this article, the proto-oncogene c-myc was found to activate expression of a cluster of six miRNAs on human chromosome 13 and showed that miR-17-5p and miR20a are negatively regulated by E2F1.
Journal ArticleDOI
c-Myc-regulated microRNAs modulate E2F1 expression.
TL;DR: A mechanism through which c-Myc simultaneously activates E2F1 transcription and limits its translation, allowing a tightly controlled proliferative signal is revealed.
Journal ArticleDOI
MYC on the Path to Cancer
TL;DR: The richness of the understanding of MYC is reviewed, highlighting new biological insights and opportunities for cancer therapies.
Journal ArticleDOI
Otto Warburg's contributions to current concepts of cancer metabolism
TL;DR: Otto Warburg's observations are re-examine in relation to the current concepts of cancer metabolism as being intimately linked to alterations of mitochondrial DNA, oncogenes and tumour suppressors, and thus readily exploitable for cancer therapy.