Kristoffer Larsen

TL;DR: Findings indicate a correlation between recruited fibrocytes in tissue and thickness of basement membrane and fibroblast progenitor cells may be important in airway remodeling in steroid-naive patients with mild asthma.

TL;DR: Airway remodelling refers to a wide pattern of patophysiological mechanisms involving smooth muscle cell hyperplasia, increase of activated fibroblasts and myofibroblast with deposition of extracellular matrix in asthma, which includes alterations of the epithelial cell layer with goblet cellhyperplasia.

TL;DR: The findings indicate the presence of activated and mobile fibroblasts accompanied by an induced inflammatory response outside the airway epithelium in patients with mild asthma, results that may play a role in formation of airway fibrosis.

TL;DR: A possible origin for fibroblasts in the airway lumen in patients with SSc is demonstrated and important differences between fibroblast phenotypes in mild asthma and SSc are shown.

TL;DR: This is the first evidence of alterations in the proteoglycan expression pattern of versican, perlecan, biglycan and decorin which can be linked to the pathophysiological state of asthmatics proven by a combination of solid‐phase extraction by reversed phase and by peptide mass fingerprinting using matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry.