Compositions for retarding skin aging which contain an edible herb drug made in Taiwan (in particular a plant extract having effects of inhibiting melamine formation, inhibiting elastase, inhibiting hyaluronidase and eliminating active oxygen and an antioxidative effect of the radical-capturing type) together with a medicinally acceptable base and/or additives for external administration to the skin. These compositions are useful in promoting whitening, contribution to the maintenance of the tension and elasticity of the skin, facilitation of skin moistening and exertion of anti-inflammatory and ant allergic effects on the skin.

Compositions for retarding skin aging

PROBLEM TO BE SOLVED: To provide a skin care preparation which is compatible with the skin and can exhibit a high skin moisture-retaining effect, a high skin-beautifying effect and a high skin roughness-improving effect. SOLUTION: This skin care preparation contains an extract of Chamaenerion angustifolium (L.) Scop. or Epilobium angustifolium L., and an extract of one or more plants selected from Calendula officinalis L., Petroselinum crispum (Mill.), Melissa officinalis L, Tussilago farfara L., Althaea officinalis L., Aesculus turbinata Blume or Aesculus hippocastanum L., Daucus carota L., Potentilla tormentilla, Hypericum erectum Thunb. or Hypericum perforatum L., Salvia officinalis L., Cucumis sativus L., Foeniculum vulgare Miller, Sambucus nigra L., Arnica montana L., Ononis spinosa L., Geranium nepalense Sweet. var. thunbergii (Sieb. et Zucc.) Kudo, Carthamas tinctorius L., Ophelia japonica (Schult.) Griseb., Saponaria officinalis L., Apium graveloens L. var. dulce (Mill.) Pers., Melilotuis officinalis L., Luffa cylindrica (L.) Roem, Saxifraga stolonifera Meerb., Paeonia suffruticosa Andr., Malva sylvestris L., Hamamelis virginiana L., Ziziphus jujuba Mill., Coptis japonica (Thunb.) Makino, Paeonia lactiflora Pall., Angelica acutiloba (Sieb. et Zucc.) Kitagawa, Cnidium officinale Malino, Asiarum sieboldi (miq.) F. Maekawa, Scutellaria baicalensis Georgi, Uncaria gambir (Hunt) Rocb., Poria cocos (Fr.) Wolf, Rehmannia glutinosa (Gaertn.) Libosch., Cinnamomi cassia Presl., Phellodendron amurense Pupr., Phellodendron amurense Pupr., Curcuma domestica Valet., Syzygium aromaticum (L.) Merril et Perry, Artemisia princeps Pamp., Zingiber officinale Rosc., Ganoderma lucidum (Leyss. ex Fr.) Karst, Coix lachryma-jobi L., Prunus armeniaca L., Prunus persica (L.) Batsch, Citrus junos Sieb. et Tanaka, Pueraria lobata (Willd.) Ohwi, Citrus unshiu Marcovitch, and Cuminum cyminum L., and fungi. COPYRIGHT: (C)2004,JPO

Skin care preparation

A composition comprising tranexamic acid or its salt (i) and L-cysteine or its derivative or a salt thereof (ii) optionally together with L-ascorbic acid or its derivative or a salt thereof (iii).

Skin lightening composition

The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and non­toxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2­furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.

Anti-sickling agents

PROBLEM TO BE SOLVED: To prevent the itchiness caused by mechanical stimulation, heat stimulation, allergic dermatitis, etc. SOLUTION: The itchiness preventing skin care preparation contains a specific Japanese or Chinese herb drug such as Banrankon (root of Isatis tinctoria), frankincense, etc., and a herb extract as active components. The skin care preparation may further contain glycyrrhizinic acid and/or its derivative in combination with the specific Japanese or Chinese herb drug and the herb extract.

Skin care preparation for preventing itchiness

PROBLEM TO BE SOLVED: To obtain the subject inhibitor having testosterone-5-reductase inhibiting action and useful as a preventive and/or therapeutic agent of depilation, acne, prostatomegbly, prostatic cancer, etc., by including a specific xanthone or its salt as an active ingredient. SOLUTION: This inhibitor contains a xanthone derivative represented by the formula (R1 to R8 is H, an alkyl, an alkenyl, an alkoxy or the like), e.g. 1,3,6-trihydroxy-7-methoxy-2,8-bis-(3-methyl-2-butenyl)xanthine-9-one( α-mangosteen) or its salt as an active ingredient. Furthermore, it is preferable that the above derivative is one or two or more kinds of extracts of each higher plant belonging to the family Guttiferae, Gentianaceae, Moraceae, Polygalaceae or Liliaceae and each lichen or fungus of the family Parmeloaceae, Pertusariaceae, Aspergillaceae or Clavicipitaceae and the xanthone derivative is preferably formulated in an amount of 0.0001-20 wt.%.

Testosterone-5-alpha-reductase inhibitor

PROBLEM TO BE SOLVED: To obtain an agent for improving liver spot or freckle which is cosmetically undesirable for women or effectively bleaching the skin. SOLUTION: The subject bleaching agent or the dyspigmentation-improving agent comprises an extract obtained by extracting immature citrus fruits with an alcohol. COPYRIGHT: (C)2005,JPO&NCIPI

Bleaching agent or dyspigmentation-improving agent

PURPOSE:To obtain a safe medicine effective in improving and treating diseases due to peripheral circulatory failure such as weak constitution, fatigue, feeling of cold or stiffness of the shoulder CONSTITUTION:This blood flow improver is characterized by including extracts obtained by extracting steam-dried Rehmanniae Radix with >=30% ethanol solution as active ingredients

Blood flow improver

PROBLEM TO BE SOLVED: To provide a method for producing citrus juice residue powder by which powder sufficiently having function of functional components contained in citrus-juice residue and unripe citrus scarcely containing juice, and inexpensively produced, not damaged in natural color and flavor (taste and aroma) in the citrus and the unripe citrus scarcely containing juice is produced: and to provide powder produced by the method and mixture further reinforcing respective functions of the functional components. SOLUTION: The method for producing citrus-juice residue powder comprises the following process: cleaning residue generated after squeezing citrus fruits with water; rapidly freezing the residue; storing the frozen residue in a cold reserving chamber; thawing the frozen residue; slicing the thawed residue; drying the sliced residue with a dryer using far-infrared ray to reduce moisture down to ≤5%; and pulverizing the dried residue with a powder producing machine. COPYRIGHT: (C)2005,JPO&NCIPI

Method for producing citrus-juice residue powder, method for producing unripe-citrus powder scarcely containing juice, and powder and mixture obtained by the method

PROBLEM TO BE SOLVED: To obtain an indole glycoside having bloodstream accelerating effect and skin whitening effect by isolation from Calanthe discolor Lindl SOLUTION: This new indole glycoside is 3β-Dglucopyranosyl(1→6)β- Dglucopyranosylindole (hereafter referred to as calanthoside A) This glycoside is obtained by the following process: rootstocks of Calanthe discolor Lindl are sliced, and subjected to hot extraction with methanol followed by partition extraction with ethyl acetate and water, and the resultant aqueous phase is put to reversed-phase silica gel column chromatography followed by successive elution with water and methanol to afford a methanol elute, which, in turn, is subjected to two-stage fractionation by normal-phase silica gel column chromatography followed by repeated separation using reversed-phase high- performance liquid chromatography Calanthoside A significantly raises rat skin's blood circulation promoting effect, having melanogenetic enzyme tyrosinase activity-suppressive effect, thus being usable in hair growers and skin whitening agents

Kubo Michitoku

Papers

Testosterone-5-alpha-reductase inhibitor

Bleaching agent or dyspigmentation-improving agent

Blood flow improver

Method for producing citrus-juice residue powder, method for producing unripe-citrus powder scarcely containing juice, and powder and mixture obtained by the method

New indole glycoside