Kun Shen

TL;DR: A copper-catalyzed amino lactonization of unsaturated carboxylic acids has been achieved as well as the analogous intermolecular three-component amino oxygenation of olefins, offering a novel and efficient approach to construct a wide range of amino lactones as wellAs 1,2-amino alcohol derivatives.

TL;DR: A copper-catalyzed aminoazidation of unactivated alkenes is achieved for the synthesis of versatile unsymmetrical 1,2-diamine derivatives, providing an efficient strategy to introduce azide, one of the most useful chemical reporters, onto a broad range of bioactive azaheterocycles, offering new opportunities in bioorthogonal chemistry and biological studies.

TL;DR: A copper-catalyzed regio- and stereoselective diamination of unactivated alkenes has been developed with O-acylhydroxylamines as electrophilic nitrogen sources and oxidants.

TL;DR: A water-soluble polarization transfer catalyst is used to hyperpolarize nitrogen-15 in a variety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei) and this strategy works in pure H2O or D2O solutions, on substrates that could not behyperpolarized in traditional 1H-SABRE experiments.

TL;DR: The generality of this approach is shown by illustrating that the diazirine tag alone is sufficient for achieving excellent signal enhancements with long-lasting polarization, and reveals the critical role of Lewis basic additives, including water, on achieving SABRE-promoted hyperpolarization.