Kun Zhang

TL;DR: The findings suggest that an extracorporeal ultrasound device can non-invasively enhance homogenous tumor targeting and SDT toxicity of EXO-DVDMS, and the developed endogenous nano-sonosensitizer is a promising nanoplatform for activated cancer theranostics.

TL;DR: In this paper, the authors developed pluronic P123/F127 polymeric micelles encapsulating curcumin (Cur) that are permeabilized directly by focused ultrasound, in which ultrasound triggers drug release.

TL;DR: A smart "all-in-one" nanosensitizer platform is designed by incorporating the sonoactive chlorin e6 and an autophagy inhibitor-hydroxychloroquine into angiopep-2 peptide-modified liposomes (designated as ACHL), which integrates multiple diagnostic and therapeutic functions, exhibiting an improved therapeutic efficiency.

TL;DR: Investigation of the sonoactivity of a novel sensitizer, sinoporphyrin sodium (DVDMS), and its sonotoxicity in an esophageal cancer cell line suggested that DVDMS could be activated by ultrasound, and that DVD MS mediates SDT-induced mitochondrial-dependent apoptosis in ECA-109 cells via production of ROS.

TL;DR: A natural and safe transportation system using FUS to increase the targeted delivery of Exos for glioma therapy and the combination of FUS and naturally abundant B-Exos is a potent strategy for brain cancer therapeutics are demonstrated.