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Showing papers by "Kunisuke Izawa published in 2015"

Journal Article•DOI•
Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by sequential SN2–SN2′ dialkylation of (R)-N-(benzyl)proline-derived glycine Schiff base Ni(II) complex

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Aki Kawashima, Chen Xie1, Haibo Mei1, Ryosuke Takeda, Akie Kawamura, Tatsunori Sato, Hiroki Moriwaki, Kunisuke Izawa, Jianlin Han1, José Luis Aceña2, Vadim A. Soloshonok2, Vadim A. Soloshonok3 •
Nanjing University1, University of the Basque Country2, Ikerbasque3
01 Jan 2015-RSC Advances
TL;DR: In this article, a new process for the asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid of high pharmaceutical importance is described.
Abstract: This work describes a new process for the asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid of high pharmaceutical importance The sequence of the reactions includes PTC alkylation (SN2), homogeneous SN2′ cyclization followed by disassembly of the resultant Ni(II) complex All reactions are conducted under operationally convenient conditions and suitably scaled up to 6 g of the starting Ni(II) complex

25 citations