scispace - formally typeset
Search or ask a question

Showing papers by "Kunzer Aaron R published in 2012"

Patent•
8-carbamoyl-2- (2,3-di-substituted pyrid-6-yl) -1,2,3,4-tetrahydroisoquinoline derivatives as apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases

[...]

Le Wang1, George Doherty1, Xilu Wang1, Zhi-Fu Tao1, Milan Brunko1, Kunzer Aaron R1, Michael D. Wendt1, Xiaohong Song1, Robin R. Frey1, Todd M. Hansen1, Gerard M. Sullivan1, Andrew S. Judd1, Andrew J. Souers1 •
AbbVie1
11 Oct 2012
TL;DR: In this paper, compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl xL proteins are expressed, eg cancer.
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.

17 citations

Patent•
Apoptosis-induced agents for the treatment of cancer and immune and autoimmune diseases

[...]

Le Wang1, George Doherty1, Xilu Wang1, Zhi-Fu Tao1, Milan Bruncko1, Kunzer Aaron R1, Michael D. Wendt1, Xiaohong Song1, Robin R. Frey1, Todd M. Hansen1, Gerard M. Sullivan1, Andrew S. Judd1, Andrew J. Souers1 •
AbbVie1
11 Oct 2012
TL;DR: In this article, compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-APOPotic BCL-xl protein.
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

2 citations

Patent•
Agents d'induction de l'apoptose pour traitement du cancer et de maladies immunitaires et auto-immunes

[...]

Le Wang, George Doherty, Wang Xilu, Zhi-Fu Tao, Milan Brunko, Kunzer Aaron R, Wendt Michael D, Xiaohong Song, Robin R. Frey, Todd M. Hansen, Gerard M. Sullivan, Andrew S. Judd, Souers Andrew J 
11 Oct 2012
TL;DR: In this paper, the authors propose a set of compositions contenant les composes and des methodes de traitement de maladies au cours desquelles est exprimee the proteine Bcl-xL anti-apoptotique.
Abstract: L'invention concerne des composes de la formule (I), qui inhibent l'activite des proteines Bcl-xL anti-apoptotiques, des compositions contenant les composes et des methodes de traitement de maladies au cours desquelles est exprimee la proteine Bcl-xL anti-apoptotique.
Patent•
Dérivés 8-carbamoyl-2-(2,3-di-substitué pyrid-6-yl)-1,2,3,4-tétrahydroisoquinoléine en tant qu'agents induisant une apoptose pour le traitement du cancer et de maladies immunes et auto-immunes

[...]

Le Wang, George Doherty, Wang Xilu, Zhi-Fu Tao, Milan Brunko, Kunzer Aaron R, Wendt Michael D, Xiaohong Song, Robin R. Frey, Todd M. Hansen, Gerard M. Sullivan, Andrew S. Judd, Souers Andrew J 
11 Oct 2012
TL;DR: In this paper, the authors propose a set of compositions contenant les composes et des methodes de traitement de maladies durant lesquelles des proteines Bcl-xL sont exprimees, par exemple le cancer.
Abstract: L'invention concerne des composes de la formule (I), qui inhibent l'activite de proteines Bcl-xL anti-apoptotiques, des compositions contenant les composes et des methodes de traitement de maladies durant lesquelles des proteines Bcl-xL sont exprimees, par exemple le cancer. X represente heteroaryle ; Y 1 represente phenylene ou heteroarylene ; L 1 represente un lieur ; Y 2 represente cycloalkyle, cycloalcenyle, heterocycloalkyle ou heterocycloalcenyle ; Z 1 represente C(O)OR 9 , C(O)NR 10 R 11 , C(O)R 11 , NR 10 C(O)R 11 , etc.