Kwan-Woo Kim

TL;DR: The inhibitory function of 4 was confirmed based on decreases in inducible nitric oxide synthesis and cyclooxygenase-2 gene expression, and 4 was found to suppress the phosphorylation of inhibitor kappa B-α, interrupt the nuclear translocation of nuclear factor kappa A, and decrease the activation of p38 mitogen-activated protein kinase.

TL;DR: Two new nardosinone-type sesquiterpenoids along with seven known terpenoids were isolated from the rhizomes and roots of Nardostachys jatamansi DC and exhibited anti-neuroinflammatory effects by inhibiting the production of pro-inflammatory mediators.

TL;DR: Five new and four known sesquiterpenoids were isolated from Nardostachys jatamansi, and compounds 3, 4, and 8 exhibited anti-neuroinflammatory effects in LPS-stimulated BV2 microglial cells through inhibiting of NF-κB signaling pathway.

TL;DR: 6,8,1′‐tri‐O‐methylaverantin represents a potential candidate for use in the development of therapeutic agents for the regulation of neuroinflammation in neurodegenerative diseases.

TL;DR: The results suggest that the neuroprotective and anti-inflammatory effects of kuwanon C are regulated by HO-1 expression, which plays a role in both inflammatory and oxidative stress responses.