K
Kwang Hee Son
Researcher at Kigali Institute of Science and Technology
Publications - 4
Citations - 374
Kwang Hee Son is an academic researcher from Kigali Institute of Science and Technology. The author has contributed to research in topics: Aspergillus fumigatus & Sterol O-acyltransferase. The author has an hindex of 3, co-authored 4 publications receiving 358 citations.
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Journal ArticleDOI
Plasma and Hepatic Cholesterol and Hepatic Activities of 3-Hydroxy-3-methyl-glutaryl-CoA Reductase and Acyl CoA: Cholesterol Transferase Are Lower in Rats Fed Citrus Peel Extract or a Mixture of Citrus Bioflavonoids
Song Hae Bok,Sung Heui Lee,Yong Bok Park,KiHwan Bae,Kwang Hee Son,Tae Sook Jeong,Myung-Sook Choi +6 more
TL;DR: The inhibition of HMG-CoA reductase and ACAT activities resulting from the supplementation of either tangerine-peel extract or a combination of its bioflavonoids could account for the decrease in fecal neutral sterol that appears to compensate for the decreased cholesterol biosynthesis in the liver.
Journal ArticleDOI
GERI-BP001, a new inhibitor of Acyl-CoA : cholesterol acyltransferase produced by Aspergillus fumigatus F37
Tae Sook Jeong,Sung Uk Kim,Byoung-Mog Kwon,Kwang Hee Son,Young Kook Kim,Myung-Un Choi,Myung-Un Choi,Song Hae Bok +7 more
TL;DR: GERI-BP001, a new inhibitor (IC 50 50μM) of acyl-CoA: cholesterol acyltransferase (ACAT), was isolated from a culture broth of Aspergillus fumigatus F37 and the structure elucidated on the basis of spectroscopic data.
Journal ArticleDOI
Amplification of farnesyl protein transferase inhibitory activity from Aspergillus fumigatus F93 by Plackett-Burman design
Kwang Hee Son,Young Kook Kim,Hyun Woo Lee,Woo-Sang Lee,Sung Uk Kim,Tae Sook Jeong,Byoung-Mog Kwon,Song Hae Bok +7 more
TL;DR: Fermentation optimization for the fungus Aspergillus fumigatus F93 was performed to amplify the most promising biological activity and selected parameters were confirmed by separate experiments in the optimized fermentation condition.
Journal ArticleDOI
Cytotoxicity of a novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane against human tumor cellsin vitro
Sang Un Choi,Kwang Hee Kim,Nam Young Kim,Eun Jung Choi,Chong Ock Lee,Kwang Hee Son,Sung Uk Kim,Song Hae Bok,Young Kook Kim +8 more
TL;DR: A novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane (GERI-BP002-A) was isolated from the fermentation broth of Aspergillus fumigatus F93 previously, and it has revealed cytotoxicity against human solid tumor cells.