K
Kwang Pak
Researcher at University of California, San Diego
Publications - 77
Citations - 1864
Kwang Pak is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Otitis & Hair cell. The author has an hindex of 25, co-authored 71 publications receiving 1627 citations. Previous affiliations of Kwang Pak include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin.
TL;DR: The results suggest that hROS accumulation is an important initial step in gentamicin-induced HC damage, and that the differential sensitivity of HCs in the organ of Corti is closely related to differences in hR OS accumulation.
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Myeloid Differentiation Primary Response Gene 88 Is Required for the Resolution of Otitis Media
Michelle L. Hernandez,Michelle L. Hernandez,Anke Leichtle,Anke Leichtle,Kwang Pak,Joerg Ebmeyer,Joerg Ebmeyer,Sara Euteneuer,Sara Euteneuer,Marygorret Obonyo,Donald G. Guiney,Nicholas J. G. Webster,David H. Broide,Allen F. Ryan,Stephen I. Wasserman +14 more
TL;DR: In this mouse model, MyD88-mediated signaling was important for clearance of infection and resolution of inflammation in acute OM due to NTHi, and the role played by innate signaling in children susceptible to chronic or recurrent OM deserves further study.
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TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media
Anke Leichtle,Michelle L. Hernandez,Kwang Pak,Kenshi Yamasaki,Chun-Fang Cheng,Nicholas J. G. Webster,Allen F. Ryan,Stephen I. Wasserman +7 more
TL;DR: Results demonstrate that both TLR2 and TLR4 signalling are critical to the regulation of infection in non-typeable H. influenzae-induced otitis media.
Journal ArticleDOI
EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and -B3.
Dominik Brors,Daniel Bodmer,Kwang Pak,Christoph Aletsee,Maria Schäfers,Stefan Dazert,Allen F. Ryan +6 more
TL;DR: The results suggest that EphA4 provides repulsive signals to SG neurites in the developing cochlea, and that ephrin‐B2 and ‐B3 together mediate this response.
Journal ArticleDOI
Involvement of ras activation in toxic hair cell damage of the mammalian cochlea.
TL;DR: The Ras inhibitors B581 and FTI-277 provided potent protection against damage and reduced c-Jun activation in HC nuclei, suggesting that activation of Ras is functionally involved in damage to these cells due to gentamicin.