L
L. A. B. Joosten
Researcher at Radboud University Nijmegen
Publications - 51
Citations - 2301
L. A. B. Joosten is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Arthritis & Chondrocyte. The author has an hindex of 19, co-authored 51 publications receiving 2240 citations. Previous affiliations of L. A. B. Joosten include Iuliu Hațieganu University of Medicine and Pharmacy.
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Journal ArticleDOI
Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction.
L. A. B. Joosten,E Lubberts,P. Durez,Monique M. Helsen,M. J. M. Jacobs,Michel Goldman,W.B. van den Berg +6 more
TL;DR: The data are consistent with a dominant role of IL-10 in the natural suppression of arthritis expression, whereas combined treatment with IL-4 andIL-10 appears of potential therapeutic value, not only at the onset, but also in established arthritis.
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Role of Interleukin-1, Tumor Necrosis Factor alpha and Interleukin-6 in cartilage proteoglycan metabolism and destruction: effect of in situ blocking in murine antigen- and zymosan-induced arthritis
TL;DR: The suppression of PG synthesis in both ZIA and AIA in mice is due to the combined local action of IL-1 (alpha + beta), and neither IL-6 nor TNF is involved.
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Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment.
TL;DR: It is concluded that IL‐1 is an important determinant in both inflammation and cartilage destruction in collagen arthritis, and this may have implications for therapy in human arthritis.
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Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee
A. C. Bakker,L. A. B. Joosten,Onno J. Arntz,Monique M. Helsen,Alison M. Bendele,F.A.J. van de Loo,W.B. van den Berg +6 more
TL;DR: Local production of HuIL-1Ra in the knee was able to ameliorate the effects of IL-1 on cartilage and could prevent the onset of CIA not only in that knee, but also in the "draining" paw, indicating the feasibility of gene transfer as a therapeutic approach to modulating arthritis.
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Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice.
TL;DR: The data indicate that antigenic charge is an important determinant of antigen handling by the joint and, in addition, support the concept that the development of chronic arthritis depends on the amount of antigen retained in the joint.