We study the design and radiation performance of novel miniature antennas for integration in head-implanted medical devices operating in the MICS (402.0-405.0 MHz) and ISM (433.1-434.8, 868.0-868.6 and 902.8-928.0 MHz) bands. A parametric model of a skin-implantable antenna is proposed, and a prototype is fabricated and tested. To speed-up antenna design, a two-step methodology is suggested. This involves approximate antenna design inside a simplified geometry and further Quasi-Newton optimization inside a canonical model of the intended implantation site. Antennas are further analyzed inside an anatomical human head model. Results indicate strong dependence of the exhibited radiation performance (radiation pattern, gain, specific absorption rate and quality of communication with exterior equipment) on design parameters and operation frequency. The study provides valuable insight into the design of implantable antennas, addressing the suitability of canonical against anatomical tissue models for design purposes, and assessing patient safety and link budget at various frequencies. Finite Element and Finite Difference Time Domain numerical solvers are used at different stages of the antenna design and analysis procedures to suit specific needs. The proposed design methodology can be applied to optimize antennas for several implantation scenarios and biotelemetry applications.

Miniature Scalp-Implantable Antennas for Telemetry in the MICS and ISM Bands: Design, Safety Considerations and Link Budget Analysis

The design procedure, realization and measurements of an implantable radiator for telemetry applications are presented. First, free space analysis allows the choice of the antenna typology with reduced computation time. Subsequently the antenna, inserted in a body phantom, is designed to take into account all the necessary electronic components, power supply and bio-compatible insulation so as to realize a complete implantable device. The conformal design has suitable dimensions for subcutaneous implantation (10 × 32.1 mm). The effect of different body phantoms is discussed. The radiator works in both the Medical Device Radiocommunication Service (MedRadio, 401-406 MHz) and the Industrial, Scientific and Medical (ISM, 2.4-2.5 GHz) bands. Simulated maximum gains attain -28.8 and - 18.5 dBi in the two desired frequency ranges, respectively, when the radiator is implanted subcutaneously in a homogenous cylindrical body phantom (80 × 110 mm) with muscle equivalent dielectric properties. Three antennas are realized and characterized in order to improve simulation calibration, electromagnetic performance, and to validate the repeatability of the manufacturing process. Measurements are also presented and a good correspondence with theoretical predictions is registered.

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Design, Realization and Measurements of a Miniature Antenna for Implantable Wireless Communication Systems

Wireless medical telemetry permits the measurement of physiological signals at a distance through wireless technologies. One of the latest applications is in the field of implantable and ingestible medical devices (IIMDs) with integrated antennas for wireless radiofrequency (RF) communication (telemetry) with exterior monitoring/control equipment. Implantable medical devices (MDs) perform an expanding variety of diagnostic and therapeutic functions, while ingestible MDs receive significant attention in gastrointestinal endoscopy. Design of such wireless IIMD telemetry systems is highly intriguing and deals with issues related to: operation frequency selection, electronics and powering, antenna design and performance, and modeling of the wireless channel. In this paper, we attempt to comparatively review the current status and challenges of IIMDs with wireless telemetry functionalities. Full solutions of commercial IIMDs are also recorded. The objective is to provide a comprehensive reference for scientists and developers in the field, while indicating directions for future research.

Implantable and ingestible medical devices with wireless telemetry functionalities: a review of current status and challenges.

This work presents the analysis of the influence of insulation on implanted antennas for biotelemetry applications in the Medical Device Radiocommunications Service band. Our goal is finding the insulation properties that facilitate power transmission, thus enhancing the communication between the implanted antenna and an external receiver. For this purpose, it has been found that a simplified model of human tissues based on spherical geometries excited by ideal sources (electric dipole, magnetic dipole and Huygens source) provides reasonable accuracy while remaining very tractable due to its analytical formulation. Our results show that a proper choice of the biocompatible internal insulation material can improve the radiation efficiency of the implanted antenna (up to six times for the investigated cases). External insulation facilitates the electromagnetic transition from the biological tissue to the outer free space, reducing the power absorbed by the human body. Summarizing, this work gives insights on the enhancement of power transmission, obtained with the use of both internal, biocompatible and external, flexible insulations. Therefore, it provides useful information for the design of implanted antennas.

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The Effect of Insulating Layers on the Performance of Implanted Antennas

The gastrointestinal (GI) tract offers the opportunity to detect physiological and pathophysiological signals from the human body. Ingestible electronics can gain close proximity to major organs through the GI tract and therefore can serve as clinical tools for diagnostics and therapy. In this Review, we summarize the physiological and anatomical characteristics of the GI tract, which present both challenges and opportunities for the development of ingestible devices. We describe recent breakthroughs in materials science, electrical engineering and data science that have permitted the exploration of technologies for sensing and therapy via the GI tract. Novel sensing opportunities include electrochemical, electromagnetic, optical and acoustic protocols, which have the capacity to sense luminal or extra-luminal analytes in the GI tract. We review therapeutic interventions, such as anatomical targeting for drug delivery, delivery of macromolecules and electrical signals. Finally, we investigate major challenges associated with ingestible electronics, including safety, communication, powering, steering and tissue interactions. Ingestible electronics are an exciting area of scientific innovation and they may pave the way for a new era in medicine, enabling patients to receive remote, electronically assisted health care. Ingestible electronics can be used as clinical tools for diagnosis and therapy. In this Review, the authors discuss clinical applications of ingestible electronic devices and highlight materials and sensor technologies, drug delivery applications and major challenges and opportunities for clinical translation, such as safety, powering and communication.

Ingestible electronics for diagnostics and therapy

The conventional method of diagnosing disorders of the human gastro-intestinal (GI) tract is by sensors embedded in cannulae that are inserted through the anus, mouth, or nose. However, these cannulae cause significant patient discomfort and cannot be used in the small intestine. As a result, there is considerable ongoing work in developing wireless sensors that can be used in the small intestine. The radiation characteristics of sources in the GI tract cannot be readily calculated due to the complexity of the human body and its composite tissues, each with different electrical characteristics. In addition, the compact antennas used are electrically small, making them inefficient radiators. This paper presents radiation characteristics for sources in the GI tract that should allow for the optimum design of more efficient telemetry systems. The characteristics are determined using the finite-difference time-domain method with a realistic antenna model on an established fully segmented human body model. Radiation intensity outside the body was found to have a Gaussian-form relationship with frequency. Maximum radiation occurs between 450 and 900 MHz. The gut region was found generally to inhibit vertically polarized electric fields more than horizontally polarized fields.

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Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz

The performance of wireless devices, using electrically small antennae, in the human intestine is investigated using the finite difference time domain method in recommended biomedical device telemetry bands. The radiation field intensity was found to depend on position but more strongly on frequency, with a transmission peak at 650 MHz.

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Radiation from ingested wireless devices in biomedical telemetry bands

There is currently considerable work on the development of wireless sensors that can be used in the small intestine. The radiation characteristics of sources in the gastro-intestinal (GI) tract cannot be readily calculated due to the complexity of the human body and its composite tissues, each with different electrical characteristics. This paper presents radiation characteristics for sources in the GI tract that should allow for the optimum design of more efficient telemetry systems. The characteristics are determined using the finite difference time domain method with a realistic antenna model on an established fully segmented human body model. Maximum radiation was found to occur between 450 and 900 MHz and the gut region was found generally to inhibit vertically polarized electric fields more than horizontally polarized fields.

L.C. Chirwa

Papers

Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz

Radiation from ingested wireless devices in biomedical telemetry bands

Electromagnetic radiation from ingested sources in the human intestine