L G Moore

TL;DR: It is suggested that oxytocin, which is considered to be released in association with N-I/II, may play an important role in ovine luteolysis by stimulating the secretion of prostaglandin F from the uterus during days 13-15 of the estrous cycle.

TL;DR: There is an increase in the responsiveness of the uterine-PGF secretory system to oxytocin during the latter stages of the estrous cycle and during early pregnancy this response was blocked by the presence of the embryo.

TL;DR: The observation that exogenous progestogens in the intact ewes did not influence the number and peak height of the OT-N surges, indicates that a fall in progesterone levels during the normal cycle is not obligatory for oxytocin release although it may facilitate the release of uterine PGF2 alpha.

TL;DR: It was found that the transfer of an embryo, on either Day 12 or 13, to the uterus of a non-pregnant sheep inhibited the pulsatile release of OT-N, suggesting that in the early pregnant sheep, the embryo may prevent corpus luteum regression by suppressing the pulsatility release of maternal oxytocin.

TL;DR: Investigation of the effect of systemic or intrauterine injections of indomethacin on peripheral plasma oxytocin-associated neurophysin (OT-N) concentrations in ewes over the time of expected luteolysis indicated that surges in plasma OT-N concentrations occurred in the vehicle-treated eWes but were suppressed in eewes given systemic injections.