L
L Saiman
Researcher at Columbia University
Publications - 3
Citations - 187
L Saiman is an academic researcher from Columbia University. The author has contributed to research in topics: Pseudomonas aeruginosa & Neuraminidase. The author has an hindex of 3, co-authored 3 publications receiving 184 citations.
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Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression.
TL;DR: The properties of the PAO1 neuraminidase were examined to determine its potential role in facilitating Pseudomonas colonization of the respiratory epithelium and under the hyperosmolar conditions postulated to exist in the CF lung, nanA is likely to be expressed to facilitate the initial adherence of Pseudomanas to the respiratory tract.
Journal ArticleDOI
Pseudomonas cepacia adherence to respiratory epithelial cells is enhanced by Pseudomonas aeruginosa.
L Saiman,G Cacalano,Alice Prince +2 more
TL;DR: There appears to be a synergistic relationship between P. aeruginosa and P. cepacia in which PAO1 exoproducts modify the epithelial cell surface, exposing receptors and facilitating increased P.cepacia attachment.
Journal ArticleDOI
Cross-reactivity of Pseudomonas aeruginosa antipilin monoclonal antibodies with heterogeneous strains of P. aeruginosa and Pseudomonas cepacia.
L Saiman,J Sadoff,Alice Prince +2 more
TL;DR: While antibodies to Pseudomonas pili must be shown to be protective in patients with CF, these studies give support for a multivalent vaccine strategy using P. aeruginosa pilin as the immunogen.