L
Laetitia Davidovic
Researcher at French Institute of Health and Medical Research
Publications - 28
Citations - 1474
Laetitia Davidovic is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 20 publications receiving 1357 citations. Previous affiliations of Laetitia Davidovic include Laval University.
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Journal ArticleDOI
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.
TL;DR: The question of its putative nucleo-cytoplasmic shuttling that could enable the tight regulation of pADPr metabolism would contribute to the elucidation of the biological significance of poly(ADP-ribosyl)ation.
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The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers
Eugene V. Koonin,Kira S. Makarova,Igor B. Rogozin,Laetitia Davidovic,Marie-Claude Letellier,Luca Pellegrini +5 more
TL;DR: Although the near-universal presence of the rhomboid family in bacteria, archaea and eukaryotes appears to suggest that this protein is part of the heritage of the last universal common ancestor, phylogenetic tree analysis indicates a likely bacterial origin with subsequent dissemination by horizontal gene transfer.
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Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles.
Edouard W. Khandjian,Marc-Étienne Huot,Sandra Tremblay,Laetitia Davidovic,Rachid Mazroui,Barbara Bardoni +5 more
TL;DR: It is demonstrated that, in the brain, FMRP is present in actively translating polyribosomes, and it is shown that this association is acutely sensitive to the type of detergent required to release poly ribosomes from membranous structures.
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The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules
Laetitia Davidovic,Xavier H. Jaglin,Aude-Marie Lepagnol-Bestel,Sandra Tremblay,Michel Simonneau,Barbara Bardoni,Edouard W. Khandjian +6 more
TL;DR: It is proposed that, in addition to modulate the translation of its mRNA targets, FMRP acts also as a molecular adaptor between RNA granules and the neurospecific kinesin KIF3C that powers their transport along neuronal microtubules.
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Dicer-Derived MicroRNAs Are Utilized by the Fragile X Mental Retardation Protein for Assembly on Target RNAs
Isabelle Plante,Laetitia Davidovic,Dominique L. Ouellet,Lise-Andrée Gobeil,Sandra Tremblay,Edouard W. Khandjian,Patrick Provost +6 more
TL;DR: It is demonstrated that human FMRP can act as a miRNA acceptor protein for the ribonuclease Dicer and facilitate the assembly of miRNAs on specific target RNA sequences and define a possible role for FMRp in RNA silencing and may provide further insight into the molecular defects in patients with the fragile X syndrome.