M
Michel Simonneau
Researcher at École Normale Supérieure
Publications - 89
Citations - 3330
Michel Simonneau is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Gene & Neural crest. The author has an hindex of 28, co-authored 84 publications receiving 3083 citations. Previous affiliations of Michel Simonneau include École normale supérieure de Cachan & Paris Descartes University.
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Journal ArticleDOI
Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome
Jeanne Amiel,Béatrice Laudier,Tania Attié-Bitach,Ha Trang,Loïc de Pontual,Blanca Gener,Delphine Trochet,Heather C. Etchevers,Pierre F. Ray,Michel Simonneau,Michel Vekemans,Arnold Munnich,Claude Gaultier,Stanislas Lyonnet +13 more
TL;DR: An essential role of PHOX2B in the normal patterning of the autonomous ventilation system and, more generally, of the autonomic nervous system in humans is supported.
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Modulation of the respiratory rhythm generator by the pontine noradrenergic A5 and A6 groups in rodents
TL;DR: The aim of the present review is to summarise available studies dealing with the respiratory control exerted by pontine noradrenergic neurones in neonatal and adult mammals, showing that the A5-A6 modulation of the respiratory rhythm generator is not transient, occurring solely during the perinatal period but it persists throughout life.
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The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules
Laetitia Davidovic,Xavier H. Jaglin,Aude-Marie Lepagnol-Bestel,Sandra Tremblay,Michel Simonneau,Barbara Bardoni,Edouard W. Khandjian +6 more
TL;DR: It is proposed that, in addition to modulate the translation of its mRNA targets, FMRP acts also as a molecular adaptor between RNA granules and the neurospecific kinesin KIF3C that powers their transport along neuronal microtubules.
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DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome
Aude-Marie Lepagnol-Bestel,Ágnes Zvara,Gilles Maussion,Frédérique Quignon,Bedel Ngimbous,Nicolas Ramoz,Sandrine Imbeaud,Yann Loe-Mie,Karim Benihoud,Nicolas Agier,Paul A. Salin,Ana Cardona,Suonavy Khung-Savatovsky,Pekka Kallunki,Jean-Maurice Delabar,László G. Puskás,Hervé Delacroix,Lawrence Aggerbeck,Anne Lise Delezoide,Olivier Delattre,Philip Gorwood,Jean Marie Moalic,Michel Simonneau +22 more
TL;DR: It is proposed that DYRK1A overexpression-related neuronal gene deregulation via disturbance of REST/ NRSF levels, and the REST/NRSF-SWI/SNF chromatin remodelling complex, significantly contributes to the neural phenotypic changes that characterize DS.
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Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors
Simon Haziza,Nitin Mohan,Yann Loe-Mie,Aude-Marie Lepagnol-Bestel,Sophie Massou,Marie-Pierre Adam,Xuan Loc Le,Julia Viard,Christine Plancon,Rachel Daudin,Pascale Koebel,Emilie Dorard,Christiane Rose,Feng-Jen Hsieh,Chih-Che Wu,Brigitte Potier,Yann Herault,Carlo Sala,Aiden Corvin,Bernadette Allinquant,Huan-Cheng Chang,François Treussart,Michel Simonneau +22 more
TL;DR: A sensitive method to measure the changes in intraneuronal transport induced by brain-disease-related genetic risk factors using fluorescent nanodiamonds (FNDs).