Laia Montoliu-Gaya

TL;DR: Not only the accumulation of the Aβ peptide is emulated but also cholesterol and insulin metabolism, which will allow for the development of more accurate animal models, which in turn will undoubtedly be helpful for bringing preclinical research closer to clinical trials in humans.

TL;DR: In this article , the authors discuss how new information on the molecular processing of brain p-tau and secretion of specific fragments into biofluids is informing blood biomarker development, enabling the evaluation of preanalytical factors that affect quantification, and informing harmonized protocols for blood handling.

TL;DR: In this article , the authors found that plasmin(tau231 and p-tau217 had the strongest association with Aβ positron emission tomography (PET) retention in early accumulating regions and associated with longitudinal increases in Aβ PET uptake in individuals without overt Aβ pathology at baseline.

TL;DR: Combined amyloid-beta and tau-directed therapies at early stages of the disease have recently been proposed as a strategy to stop the progression of Alzheimer’s disease.

TL;DR: A perspective on state-of-the-art of passive Aβ-immunotherapy in AD is provided and new structures based on antibody fragments have been engineered intending to improve efficacy and safety.