N
Nicholas J. Ashton
Researcher at University of Gothenburg
Publications - 246
Citations - 7418
Nicholas J. Ashton is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 27, co-authored 130 publications receiving 2371 citations. Previous affiliations of Nicholas J. Ashton include South London and Maudsley NHS Foundation Trust & Centre for Mental Health.
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Journal ArticleDOI
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
Thomas K. Karikari,Tharick A. Pascoal,Tharick A. Pascoal,Nicholas J. Ashton,Shorena Janelidze,Andrea Lessa Benedet,Juan Lantero Rodriguez,Mira Chamoun,Melissa Savard,Min Su Kang,Min Su Kang,Joseph Therriault,Michael Schöll,Gassan Massarweh,Jean-Paul Soucy,Kina Höglund,Kina Höglund,Gunnar Brinkmalm,Niklas Mattsson,Sebastian Palmqvist,Serge Gauthier,Erik Stomrud,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Oskar Hansson,Pedro Rosa-Neto,Pedro Rosa-Neto,Kaj Blennow,Kaj Blennow +29 more
TL;DR: Blood p-tau181 can predict tau and amyloid β pathologies, differentiate Alzheimer's disease from other neurodegenerative disorders, and identify Alzheimer's Disease across the clinical continuum.
Journal ArticleDOI
Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19.
Nelly Kanberg,Nelly Kanberg,Nicholas J. Ashton,Nicholas J. Ashton,Lars-Magnus Andersson,Lars-Magnus Andersson,Aylin Yilmaz,Aylin Yilmaz,Magnus Lindh,Staffan Nilsson,Richard W. Price,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Magnus Gisslén,Magnus Gisslén +15 more
TL;DR: Neurochemical evidence of neuronal injury and glial activation in patients with moderate and severe COVID-19 is shown, perhaps reflecting a sequence of early astrocytic response and more delayed axonal injury.
Journal ArticleDOI
Steroid-Responsive Encephalitis in Coronavirus Disease 2019.
Andrea Pilotto,Silvia Odolini,Stefano Masciocchi,Agnese Comelli,Irene Volonghi,Stefano Gazzina,Sara Nocivelli,Alessandro Pezzini,Emanuele Focà,Arnaldo Caruso,Matilde Leonardi,Maria Pia Pasolini,Roberto Gasparotti,Francesco Castelli,Nicholas J. Ashton,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Alessandro Padovani +18 more
TL;DR: A progressive clinical improvement along with a reduction of cerebrospinal fluid parameters was observed after high‐dose steroid treatment, thus arguing for an inflammatory‐mediated brain involvement related to COVID‐19.
Journal ArticleDOI
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology
Nicholas J. Ashton,Tharick A. Pascoal,Thomas K. Karikari,Andrea Lessa Benedet,Andrea Lessa Benedet,Juan Lantero-Rodriguez,Gunnar Brinkmalm,Anniina Snellman,Michael Schöll,Michael Schöll,Claire Troakes,Abdul Hye,Abdul Hye,Serge Gauthier,Eugeen Vanmechelen,Henrik Zetterberg,Pedro Rosa-Neto,Pedro Rosa-Neto,Pedro Rosa-Neto,Kaj Blennow,Kaj Blennow +20 more
TL;DR: In this paper, the authors developed an ultrasensitive Single Molecule Array (Simoa) for the quantification of plasma p-tau231 which was validated in four independent cohorts (n = 0.588) in different settings, including the full AD continuum and non-AD neurodegenerative disorders.
Journal ArticleDOI
Plasma proteins predict conversion to dementia from prodromal disease
Abdul Hye,Joanna Riddoch-Contreras,Alison L. Baird,Nicholas J. Ashton,Chantal Bazenet,Rufina Leung,Eric Westman,Eric Westman,Andrew Simmons,Richard Dobson,Martina Sattlecker,Michelle K. Lupton,Michelle K. Lupton,Katie Lunnon,Aoife Keohane,Malcolm Ward,Ian Pike,Hans Dieter Zucht,Danielle Pepin,Wei Zheng,Alan Tunnicliffe,Jill C. Richardson,Serge Gauthier,Hilkka Soininen,Iwona Kłoszewska,Patrizia Mecocci,Magda Tsolaki,Bruno Vellas,Simon Lovestone,Simon Lovestone +29 more
TL;DR: The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.