L
Lakshman Sodagam
Researcher at Aarhus University
Publications - 4
Citations - 107
Lakshman Sodagam is an academic researcher from Aarhus University. The author has contributed to research in topics: Senescence & Cell growth. The author has an hindex of 3, co-authored 4 publications receiving 86 citations.
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Journal ArticleDOI
Gerontomodulatory and Youth-Preserving Effects of Zeatin on Human Skin Fibroblasts Undergoing Aging In Vitro
TL;DR: Life-long serial passaging of human skin fibroblasts in the presence of zeatin resulted in the prevention of cell enlargement, reduction of intracellular debris, prevention of actin polymerization, and enhancement of cellular ability to decompose hydrogen peroxide and to cope with ethanol and oxidative stresses.
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Phytochemicals Rosmarinic Acid, Ampelopsin, and Amorfrutin-A Can Modulate Age-Related Phenotype of Serially Passaged Human Skin Fibroblasts in vitro.
Lakshman Sodagam,Anna Lewinska,Ewa Kwasniewicz,Sofiya Kokhanovska,Maciej Wnuk,Karsten Siems,Suresh I. S. Rattan +6 more
TL;DR: Results show that these phytochemicals do have some beneficial effects in terms of supporting the long-term lifelong growth and enhanced stress tolerance of serially passaged cells, and may be potential hormetins, which bring about their health beneficial effects by the phenomenon of mild stress-induced hormesis.
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Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro
TL;DR: It can be inferred that intermittent and episodic induction ofSR, rather than chronic up-regulation of SR, is more effective and applicable in the practice of hormesis for healthy ageing and longevity.
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Plant-Derived Molecules α-Boswellic Acid Acetate, Praeruptorin-A, and Salvianolic Acid-B Have Age-Related Differential Effects in Young and Senescent Human Fibroblasts In Vitro.
Anna Lewinska,Lakshman Sodagam,Dominika Bloniarz,Karsten Siems,Maciej Wnuk,Suresh I. S. Rattan +5 more
TL;DR: It is reported that young and near-senescent skin fibroblasts exposed for 1–15 days to a wide range of concentrations of three selected phytochemicals had age-related differential effects, and all three compounds showed biphasic hormetic dose response by stimulating cell growth, survival and metabolic activity at low doses, while showing inhibitory effects at high doses.