L
Lan Wei-LaPierre
Researcher at University of Rochester Medical Center
Publications - 13
Citations - 523
Lan Wei-LaPierre is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Skeletal muscle & Neuromuscular junction. The author has an hindex of 9, co-authored 13 publications receiving 406 citations.
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Journal ArticleDOI
Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration.
Wenxuan Liu,Alanna Klose,Sophie Forman,Nicole D. Paris,Lan Wei-LaPierre,Mariela Cortés-López,Aidi Tan,Morgan Flaherty,Pedro Miura,Robert T. Dirksen,Joe V. Chakkalakal +10 more
TL;DR: It is demonstrated that deficiencies in muscle stem cell fate and post-synaptic myogenesis provide a cellular basis for age-related neuromuscular junction degeneration and associated skeletal muscle decline.
Journal ArticleDOI
Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions
TL;DR: This work proposes a mechanism whereby further NMJ and skeletal muscle decline ensues upon SC depletion and neuromuscular disruption, and Fate analysis revealed SC activity near regenerating NMJs.
Journal ArticleDOI
Respective Contribution of Mitochondrial Superoxide and pH to Mitochondria-targeted Circularly Permuted Yellow Fluorescent Protein (mt-cpYFP) Flash Activity
Lan Wei-LaPierre,Guohua Gong,Brent Gerstner,Sylvie Ducreux,David I. Yule,Sandrine Pouvreau,Xianhua Wang,Shey-Shing Sheu,Heping Cheng,Robert T. Dirksen,Wang Wang +10 more
TL;DR: Results indicate that mt-cpYFP flash events reflect a burst in electron transport chain-dependent superoxide production that is coincident with a modest increase in matrix pH, validating mt-CPYFP as a novel superoxide sensor.
Journal ArticleDOI
Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology.
Wang Wang,Guohua Gong,Xianhua Wang,Lan Wei-LaPierre,Heping Cheng,Robert T. Dirksen,Shey-Shing Sheu +6 more
TL;DR: The history of flash discovery, current understanding of flash biology, controversies regarding the relative roles of superoxide and pH signals during a flash event, and bring forth the integration of both signals in flash genesis are reviewed.
Journal ArticleDOI
Enhanced Ca2+ influx from STIM1–Orai1 induces muscle pathology in mouse models of muscular dystrophy
Sanjeewa A. Goonasekera,Jennifer Davis,Jennifer Q. Kwong,Federica Accornero,Lan Wei-LaPierre,Michelle A. Sargent,Robert T. Dirksen,Jeffery D. Molkentin +7 more
TL;DR: Ca(2+) influx across an unstable sarcolemma due to increased activity of a STIM1-Orai1 complex is a disease determinant in muscular dystrophy, and hence, SOCE represents a potential therapeutic target.