Convergent Dendrons and Dendrimers: from Synthesis to Applications

Synthesis of glycopeptides containing carbohydrate and Peptide recognition motifs.

Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the complex oligosaccharide constructs that are needed for the systematic design and evaluation of novel vaccine formulations relies on de novo chemical synthesis. The use of both state-of-the-art and emerging glycosylation technologies has led to significant advances in this field, allowing the clinical exploration of carbohydrate-based antigens in the treatment of cancer.

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Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines

Recent trends in the synthesis of O-glycosides of 2-amino-2-deoxysugars.

Recent developments in the synthesis of oxepines

Nitrogen transfer to glycals: A new method for direct C2-aza-glycosylation with glycal donors has been developed (see scheme), employing the new reagent combination of thianthrene-S-oxide and trifluoroacetic anhydride for glycal activation, in an overall one-pot procedure.

Larry G. Huffman Jr.

Papers

Acetamidoglycosylation with Glycal Donors: A One‐Pot Glycosidic Coupling with Direct Installation of the Natural C(2)‐N‐Acetylamino Functionality

Acetamidoglycosylation with Glycal Donors: A One-Pot Glycosidic Coupling with Direct Installation of the Natural C(2)-N-Acetylamino Functionality.