1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

Thiol-ene “click” reactions and recent applications in polymer and materials synthesis

Post-polymerization modification is based on the direct polymerization or copolymerization of monomers bearing chemoselective handles that are inert towards the polymerization conditions but can be quantitatively converted in a subsequent step into a broad range of other functional groups. The success of this method is based on the excellent conversions achievable under mild conditions, the excellent functional-group tolerance, and the orthogonality of the post-polymerization modification reactions. This Review surveys different classes of reactive polymer precursors bearing chemoselective handles and discusses issues related to the preparation of these reactive polymers by direct polymerization of appropriately functionalized monomers as well as the post-polymerization modification of these precursors into functional polymers.

Synthesis of functional polymers by post-polymerization modification.

Surface coatings including microparticles immobilized in a polymeric matrix on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and utilizing microparticles immobilized via a polymeric matrix.

Particle immobilized coatings and uses thereof

Aminopyridines as acylation catalysts for tertiary alcohols

The chronology of 2-alkenyl azlactone research at 3M is discussed in terms of its origination; consideration of economics, overall safety, and opportunities for patent protection; elaboration of the chemistry; and, finally, applying lessons learned toward the development of commercial technologies. The chemistry is dominated by the presence of three electrophilic reaction centers and a readily polymerizable 2-alkenyl group. Technological development has been focused in four general areas: acrylamide monomers, acrylamide materials, azlactone materials, and polymer modification. Application areas disinclude lithographic printing plates, contact lens materials, adhesives, dispersants for printing inks, and supports for immobilizing enzymes. © 2001 John Wiley & Sons, Inc. J Polym Sci Part A: Polym Chem 39: 3655–3677, 2001

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pola.10007

Chemistry and technology of 2‐alkenyl azlactones

Cycloadditions. 24. An improved procedure for the addition of dichloroketene to unreactive olefins

Azlactone-functional substrates (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.

Larry R. Krepski

Papers

Aminopyridines as acylation catalysts for tertiary alcohols

Chemistry and technology of 2‐alkenyl azlactones

Cycloadditions. 24. An improved procedure for the addition of dichloroketene to unreactive olefins

Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof

Immobilization of Protein A at high density on azlactone-functional polymeric beads and their use in affinity chromatography