Lars Beckmann

TL;DR: The results indicate that haplotype-sharing based on Mantel statistics can be a powerful approach and needs further methodological evaluation as mentioned in this paper, however, methodological improvements are required for chromosomal regions of low to moderate LD.

TL;DR: Logistic regression with and without stepwise selection and Bayes Model Averaging were applied to a population-based case-control study exploring the association of genetic variants in tobacco smoke-related carcinogen pathways with breast cancer.

TL;DR: SDMinP is an easy-to-use program for fast calculation of empirical and adjusted P-values for correlated and uncorrelated hypotheses in multiple testing experiments and implements a variation of an efficient algorithm, which reduces the originally required re-sampling effort considerably and makes the method computationally feasible.

TL;DR: This paper summarizes the contributions of group 8 to the Genetic Analysis Workshop 15, which focused on ways to address the possibility that genetic and environmental effects on phenotype may not be independent, but instead may interact in ways that could play important roles in determining phenotype.

TL;DR: The investigated retrospective methods can be an attractive alternative to haplotype-based methods which do not account for the retrospective sampling design for the analysis of gene-environment interactions in case-control data.