L
Lars Eyde Theill
Researcher at Amgen
Publications - 19
Citations - 2442
Lars Eyde Theill is an academic researcher from Amgen. The author has contributed to research in topics: B-cell activating factor & Nucleic acid. The author has an hindex of 12, co-authored 19 publications receiving 2358 citations.
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Journal ArticleDOI
RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution
TL;DR: Modulation of these systems provides a unique opportunity to design novel therapeutics to inhibit bone loss in arthritis, periodontal disease, and osteoporosis.
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APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.
Gang Yu,Tom Boone,John M. Delaney,Nessa Hawkins,Michael J. Kelley,Meena Ramakrishnan,Susan McCabe,Wan-rong Qiu,Masayo Kornuc,Xing-Zhong Xia,Jane Guo,Marina Stolina,William J. Boyle,Ildiko Sarosi,Hailing Hsu,Giorgio Senaldi,Lars Eyde Theill +16 more
TL;DR: The tumor neurosis factor homolog APRIL stimulates in vitro proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells in vivo, indicating that APRIL and/or TALL-1 signaling via BCMA and TACI are required for generation of humoral immunity.
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TACI Is a TRAF-interacting Receptor for TALL-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation
Xing-Zhong Xia,James J. S. Treanor,Giorgio Senaldi,Sanjay D. Khare,Tom Boone,Michael J. Kelley,Lars Eyde Theill,Anne Colombero,Irina Solovyev,Frances Lee,Susan McCabe,Robin Elliott,Kent Miner,Nessa Hawkins,Jane Guo,Marina Stolina,Gang Yu,Judy Wang,John M. Delaney,Shi-Yuan Meng,William J. Boyle,Hailing Hsu +21 more
TL;DR: The identification and characterization of the receptor for TALL-1 provides useful information for the development of a treatment for B cell-mediated autoimmune diseases such as systemic lupus erythematosus.
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Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis
Gregory Scott Naeve,Meena Ramakrishnan,Rainer Kramer,Dana Hevroni,Yoav Citri,Lars Eyde Theill +5 more
TL;DR: Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures, and implicate neurit in as a downstream effector of activity-induced neuriteOutgrowth.
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Transcriptional Control of GH Expression and Anterior Pituitary Development
Lars Eyde Theill,Michael Karin +1 more
TL;DR: The molecular mechanisms underlying regulatory genes controlling developmental pathways in organisms such as Drosophila and the nematode Caenorhabditis elegans are studied.