Inflammatory bowel disease (1)

Human intestinal permeability.

The molecular cloning of the C5a receptor places this molecule in the superfamily of G-protein coupled receptors. This superfamily is characterized by the presence of signature motifs including seven hydrophobic domains which span the cell membrane and impart a predicted serpentine topology to the receptor proteins. The identification of other members of this family, including receptors for the chemokines IL-8 and Mip-1/Rantes, thrombin, formyl peptide, and platelet activating factor, provide new tools for understanding structure-function relationships relevant to the inflammatory process. This review focuses on the recent biological studies concerning the ligand C5a and its cellular receptor, the structure/activity relationships so far discerned, signal transduction mechanisms, progress toward identification of receptor antagonists, and some likely directions for future studies. Where appropriate, relevant work on related seven transmembrane segment receptors is discussed.

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

Venge P. Soluble markers of allergic inflammation.

https://www.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1398-9995.1994.tb00765.x

Soluble markers of allergic inflammation

https://www.gastrojournal.org/article/0016-5085(92)91182-4/pdf

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification.

There is evidence that complement components may be formed locally in inflammatory lesions containing monocytes and macrophages. To investigate the role of complement in Crohn's disease we measured ...

https://www.nejm.org/doi/pdf/10.1056/NEJM199005103221903

Lars Knutson

Papers

Enhanced Local Production of Complement Components in the Small Intestines of Patients with Crohn's Disease

Challenge with gliadin induces eosinophil and mast cell activation in the jejunum of patients with celiac disease.