Showing papers in "The American Journal of Medicine in 1989"

TL;DR: The classification, evaluation, and management of common symptoms need to be refined, and diagnostic strategies emphasizing organic causes may be inadequate.

TL;DR: These findings provide a quantitative basis for evaluating the risk of major bleeding in individual patients at the start of outpatient therapy with warfarin and identify predictive factors known at the beginning of therapy.

TL;DR: Increasing effort should be placed on ensuring timely administration of combination therapy to patients with P. aeruginosa bacteremia since the use of combination Therapy was even more important in determining outcome than was underlying disease.

TL;DR: In patients with diabetes and renal impairment, it may be preferable to perform angiography as a staged procedure or to utilize alternative techniques to obtain the desired information rather than to exceed the prescribed contrast limit.

TL;DR: Imbalances of the cytokine network in untreated P. falciparum infection serve as markers of severity of disease and modulation of cytokine response could represent a novel approach to the treatment of severe organ dysfunctions in human malaria.

TL;DR: In patients with AIDS, mean triglyceride levels and the prevalence of hypertriglyceridemia were similar in the presence and absence of wasting and is independent of the degree of wasting.

TL;DR: This experience suggests itraconazole may be an important advance in the therapy of aspergillosis, in contrast to previously available therapy.

TL;DR: Current knowledge about the normal function of the gastric mucosal barrier; the role of prostaglandins in cytoprotection and repair; the mechanisms by which aspirin and other weak organic acids are absorbed by the stomach; and the subsequent cascade of events--including ion trapping and back diffusion of hydrogen ions--that leads to gastric erosion and bleeding are examined.

TL;DR: Strokes were often multiple and were followed by multi-infarct dementia in nine patients and 10 patients in whom the presence of antiphospholipid antibodies was the major and often the sole immunologic disturbance present, and all patients with any of these conditions who present with vascular events should be screened for these antibodies.

TL;DR: A benefit for early amphotericin B treatment in granulocytopenic patients with continued fever despite antibiotic therapy is suggested and a difference in survival between the two groups of patients is not demonstrated.

TL;DR: Ethanol may be responsible for osteoblastic dysfunction resulting in diminished bone formation and reduced bone mineralization in alcoholic patients with histologically established alcoholic liver disease.

TL;DR: Since the dose of 125 mg appeared to be as effective as the 500-mg dose, which is more expensive, the 125-mgdose is preferred when vancomycin is used in treatment of this disease, unless the patient is critically ill.

TL;DR: This study has defined seven major risk factors for nosocomial candidemia and these findings should facilitate development of rational approaches to preventing infection and may assist clinicians in identifying those patients in whom this life-threatening complication is likely to occur.

TL;DR: Preliminary data raise the possibility of an association of chronic renal disease and the sleep apnea syndrome, and suggest that some of the daytime sleepiness and disturbed nocturnal sleep in patients with end-stage renal disease may be related toSleep apnea.

TL;DR: Decisions to withhold therapy that is deemed futile, like all treatment choices, must follow both clinical judgments about the chance of success of a therapy and an explicit consideration of the patient's goals for therapy.

TL;DR: Clinicians should be aware that profound biliary tract abnormalities may develop in a large number of human immunodeficiency virus-infected patients.

TL;DR: The PAM Index was found to correlate inversely with the frequency of successful resuscitation, and the probability of short-term and long-term survival after CPR, and may be useful in identifying patients in whom CPR may be ineffective.

TL;DR: It is proposed that activation of the complement system via the classical pathway is involved in the development of fatal complications in sepsis.

TL;DR: A prospective survey of medical inpatients to determine attitudes toward life support under differing medical outcomes, and the extent of physician communication about these issues, found that hospitalized medical patients base their preferences for life support upon perceived outcomes.

TL;DR: The results provide a valid quantitative basis for estimating the odds of bleeding in relation to the prothrombin time and the yield of diagnostic evaluation in patients with bleeding.

TL;DR: The hepatitis B surface antigen expressed in genetically manipulated yeast cells vaccine has been shown to be safe, well tolerated, and immunogenic in healthy persons of all ages and in special target groups likely to require vaccination.

TL;DR: It is concluded that cognitive errors can be identified and classified, that they can produce serious morbidity and that a classification of cognitive errors is a step toward a deeper understanding of the epidemiology, causes, and prevention of diagnostic errors.

TL;DR: The concepts of stunned myocardium are reviewed as they apply to both coronary reperfusion during evolving acute myocardial infarction, as well as brief periods of ischemia that may occur during angina pectoris, or coronary vasospasm, or both.

TL;DR: The ingestion of fish oil improves tolerance to cold exposure and delays the onset of vasospasm in patients with primary, but not secondary, Raynaud's phenomenon, and these improvements are associated with significantly increased digital systolic blood pressures in cold temperatures.

TL;DR: In patients with pulmonary Kaposi's sarcoma, combination chemotherapy consisting of ABV or BV is associated with dramatic clinical and functional improvement and the median survival of 10 months demonstrates the value of combination chemotherapy in this group of patients.

TL;DR: The data indicate that FSGS associated with HIV infection can occur before other manifestations of AIDS, is more common in blacks and in intravenous drug abusers, and is rapidly progressive to uremia.

TL;DR: A small fraction of plasma antithrombin is normally bound to a specific population of heparan sulfate proteoglycans synthesized by macrovascular and microvascular endothelial cells, which ensures the continual regeneration of the nonthrombotic properties of the endothelial cell layer.

TL;DR: This skin lesion is much more common than previously believed and has a dramatic ethnic predisposition and suggests that insulin resistance and hyperinsulinemia, with all of their serious medical implications, are also highly prevalent.

TL;DR: Two important drug-drug interactions with new quinolone antibiotics revealed decreased fluoroquinolone absorption when co-administered with magnesium-aluminum antacids and inhibition of theophylline metabolism are investigated.

TL;DR: Recommendations for developing and implementing hepatitis B immunization protocols are presented and the clinical course and immunodiagnosis of hepatitis B infection is discussed.